FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952302425> ?p ?o ?g. }

• W2952302425 endingPage "483" @default.
• W2952302425 startingPage "472" @default.
• W2952302425 abstract "BackgroundAccumulating evidence has revealed the pivotal role of epigenetic regulation in the pathogenesis of liver disease. However, the epigenetic mechanism that accounts for hepatic stellate cells (HSCs) activation in liver fibrosis remains largely unknown.MethodsPrimary HSCs were used to screen the differentially expressed histone H3 lysine methyltransferases and demethylases during HSC activation. Loss-of-function experiments were applied to determine the cellular functions of KDM4D in HSCs. Transcriptome analysis was applied to explore the downstream targets of KDM4D. Real-time qPCR, western blotting, immunohistochemical staining, and chromatin immunoprecipitation were performed to uncover the underlying mechanism concerning KDM4D during liver fibrogenesis.FindingsKDM4D was identified as a remarkable up-regulated histone H3 demethylase during HSC activation. The overexpression profile of KDM4D was confirmed in three fibrosis animal models and human fibrotic liver tissues. In vitro Kdm4d knockdown impaired the collagen gel contraction and migration capacity of primary HSCs. In established CCl4-induced mice model, Kdm4d knockdown inhibited fibrosis progression, and promoted fibrosis reversal, with enhanced thinning and splitting of fibrotic septa, as well as a dramatic decrease in collagen area. Whole gene transcriptome analysis showed the regulatory role of KDM4D in Toll-Like Receptor (TLR) signaling pathway. Mechanistically, KDM4D catalyzed histone 3 on lysine 9 (H3K9) di-, and tri-demethylation, which promoted TLR4 expression, and subsequently prompted liver fibrogenesis by activating NF-κB signaling pathways.InterpretationKDM4D facilitates TLR4 transcription through demethylation of H3K9, thus activating TLR4/NF-κB signaling pathways in HSCs, contributing to HSC activation and collagen crosslinking, further, hepatic fibrosis progression.FundShanghai New Hundred Talents Program, Shanghai Municipal Commission of Health and Family Planning, Key Developing Disciplines Program, Shanghai Key disciplines program of Health and Family Planning and Shanghai Sailing Program." @default.
• W2952302425 created "2019-06-27" @default.
• W2952302425 creator A5005348958 @default.
• W2952302425 creator A5008582313 @default.
• W2952302425 creator A5013530220 @default.
• W2952302425 creator A5024337671 @default.
• W2952302425 creator A5026289165 @default.
• W2952302425 creator A5027835055 @default.
• W2952302425 creator A5037373216 @default.
• W2952302425 creator A5039590757 @default.
• W2952302425 creator A5044029207 @default.
• W2952302425 creator A5064313237 @default.
• W2952302425 creator A5087320814 @default.
• W2952302425 date "2019-01-01" @default.
• W2952302425 modified "2023-10-12" @default.
• W2952302425 title "The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway" @default.
• W2952302425 cites W1804157788 @default.
• W2952302425 cites W1965075655 @default.
• W2952302425 cites W1965588383 @default.
• W2952302425 cites W1982484050 @default.
• W2952302425 cites W1990949301 @default.
• W2952302425 cites W1992538495 @default.
• W2952302425 cites W2000931643 @default.
• W2952302425 cites W2010711123 @default.
• W2952302425 cites W2014696364 @default.
• W2952302425 cites W2029865263 @default.
• W2952302425 cites W2042336817 @default.
• W2952302425 cites W2050834967 @default.
• W2952302425 cites W2053791243 @default.
• W2952302425 cites W2054643318 @default.
• W2952302425 cites W2063982921 @default.
• W2952302425 cites W2068157186 @default.
• W2952302425 cites W2071937747 @default.
• W2952302425 cites W2084885369 @default.
• W2952302425 cites W2088711557 @default.
• W2952302425 cites W2091491022 @default.
• W2952302425 cites W2094133741 @default.
• W2952302425 cites W2096083625 @default.
• W2952302425 cites W2104193042 @default.
• W2952302425 cites W2105482874 @default.
• W2952302425 cites W2133148543 @default.
• W2952302425 cites W2164906049 @default.
• W2952302425 cites W2214176334 @default.
• W2952302425 cites W2470223656 @default.
• W2952302425 cites W2473365874 @default.
• W2952302425 cites W2510176624 @default.
• W2952302425 cites W2562949639 @default.
• W2952302425 cites W2603930437 @default.
• W2952302425 cites W2739174192 @default.
• W2952302425 cites W2886164483 @default.
• W2952302425 cites W4212766227 @default.
• W2952302425 cites W4255712601 @default.
• W2952302425 doi "https://doi.org/10.1016/j.ebiom.2018.11.055" @default.
• W2952302425 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6354657" @default.
• W2952302425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30527625" @default.
• W2952302425 hasPublicationYear "2019" @default.
• W2952302425 type Work @default.
• W2952302425 sameAs 2952302425 @default.
• W2952302425 citedByCount "22" @default.
• W2952302425 countsByYear W29523024252019 @default.
• W2952302425 countsByYear W29523024252020 @default.
• W2952302425 countsByYear W29523024252021 @default.
• W2952302425 countsByYear W29523024252022 @default.
• W2952302425 countsByYear W29523024252023 @default.
• W2952302425 crossrefType "journal-article" @default.
• W2952302425 hasAuthorship W2952302425A5005348958 @default.
• W2952302425 hasAuthorship W2952302425A5008582313 @default.
• W2952302425 hasAuthorship W2952302425A5013530220 @default.
• W2952302425 hasAuthorship W2952302425A5024337671 @default.
• W2952302425 hasAuthorship W2952302425A5026289165 @default.
• W2952302425 hasAuthorship W2952302425A5027835055 @default.
• W2952302425 hasAuthorship W2952302425A5037373216 @default.
• W2952302425 hasAuthorship W2952302425A5039590757 @default.
• W2952302425 hasAuthorship W2952302425A5044029207 @default.
• W2952302425 hasAuthorship W2952302425A5064313237 @default.
• W2952302425 hasAuthorship W2952302425A5087320814 @default.
• W2952302425 hasBestOaLocation W29523024251 @default.
• W2952302425 hasConcept C101762097 @default.
• W2952302425 hasConcept C104317684 @default.
• W2952302425 hasConcept C134018914 @default.
• W2952302425 hasConcept C134320426 @default.
• W2952302425 hasConcept C142724271 @default.
• W2952302425 hasConcept C150194340 @default.
• W2952302425 hasConcept C173396325 @default.
• W2952302425 hasConcept C176891718 @default.
• W2952302425 hasConcept C2776745794 @default.
• W2952302425 hasConcept C2780559512 @default.
• W2952302425 hasConcept C2781364455 @default.
• W2952302425 hasConcept C2993667909 @default.
• W2952302425 hasConcept C502942594 @default.
• W2952302425 hasConcept C54355233 @default.
• W2952302425 hasConcept C55493867 @default.
• W2952302425 hasConcept C62478195 @default.
• W2952302425 hasConcept C64927066 @default.
• W2952302425 hasConcept C71924100 @default.
• W2952302425 hasConcept C81885089 @default.
• W2952302425 hasConcept C86803240 @default.
• W2952302425 hasConcept C95444343 @default.

• next