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- W2952306768 endingPage "1038" @default.
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- W2952306768 abstract "The recent introductions of low-cost, long-read, and read-cloud sequencing technologies coupled with intense efforts to develop efficient algorithms have made affordable, high-quality de novo sequence assembly a realistic proposition. The result is an explosion of new, ultracontiguous genome assemblies. To compare these genomes, we need robust methods for genome annotation. We describe the fully open source Comparative Annotation Toolkit (CAT), which provides a flexible way to simultaneously annotate entire clades and identify orthology relationships. We show that CAT can be used to improve annotations on the rat genome, annotate the great apes, annotate a diverse set of mammals, and annotate personal, diploid human genomes. We demonstrate the resulting discovery of novel genes, isoforms, and structural variants—even in genomes as well studied as rat and the great apes—and how these annotations improve cross-species RNA expression experiments." @default.
- W2952306768 created "2019-06-27" @default.
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- W2952306768 date "2018-06-08" @default.
- W2952306768 modified "2023-10-17" @default.
- W2952306768 title "Comparative Annotation Toolkit (CAT)—simultaneous clade and personal genome annotation" @default.
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- W2952306768 doi "https://doi.org/10.1101/gr.233460.117" @default.
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