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- W2952316265 abstract "Space flight and ground-based models of weightlessness result in loss of muscle mass and strength. Amino acid supplementation and resistance training reverse these losses but their optimal combination is not known. We examined the effect of an amino acid supplement and resistance training on muscle mass and strength in 18 men (31–55 y) undergoing bed rest for 28 days followed by 14 days recovery. Subjects were randomly assigned to: an amino acid supplement only (AA, n = 5); resistance training (RT, n = 6); or RT with AA given 5 min prior to training (AART, n = 7). Mid-thigh muscle area and lower body strength were measured at baseline, end of bed rest and recovery. Recovery involved resistance and treadmill exercises. Muscle area and strength were reduced after bed rest in the AA>RT>AART by 12, 4 and 3 %, respectively for thigh muscle area (P = 0.002); and by 24, 13 and 5 %, respectively for strength (P = 0.02). These parameters were restored after recovery in all groups. Re-gains in strength were seen with AART>RT>AA (120, 62 and 31% of the amount lost during bed rest, respectively; P = 0.002). The re-gains in muscle area for each respective group were 20, 33 and 29% of the amounts lost (P = 0.06). These data show that RT combined with AA or alone is a better countermeasure for the loss of muscle mass and function seen with disuse than AA alone. Our results underline the role of recovery following a period of strict bed rest. Support: NSBRI-NPFR00301 & GCRC M01 RR000054." @default.
- W2952316265 created "2019-06-27" @default.
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- W2952316265 date "2006-03-01" @default.
- W2952316265 modified "2023-10-18" @default.
- W2952316265 title "Resistance training and timed amino acid supplementation protects against the loss of muscle mass and strength with disuse" @default.
- W2952316265 doi "https://doi.org/10.1096/fasebj.20.4.a591" @default.
- W2952316265 hasPublicationYear "2006" @default.
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