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- W2952321839 abstract "A series of semicarbazones and thiosemicarbazones were synthesized and evaluated for anti-convulsant activity. Some compounds provided significant protection against Maximal Electroshock (MES) and subcutaneous strychnine induced seizures. Compound 1 was the most active in the series with activity in a dose of 30 mg/kg in the strychnine seizure pattern test and an ED50 of 10 mg/kg in the MES test. Hence it could serve as a prototype molecule for future development. Also compounds with a p-nitrophenyl substitution in place of the amino hydrogen of semicarbazone moiety showed activity in a dose of 30 mg/kg and an ED50 of 83 mg/kg in the MES test." @default.
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- W2952321839 date "1999-04-01" @default.
- W2952321839 modified "2023-09-23" @default.
- W2952321839 title "Evaluation of semicarbazones for anticonvulsant and sedative-hypnotic properties." @default.
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