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- W2952328530 abstract "Spliceosomal introns are ubiquitous non-coding RNAs that are typically destined for rapid debranching and degradation. Here we describe 34 excised introns in Saccharomyces cerevisiae that-despite being rapidly degraded in log-phase growth-accumulate as linear RNAs under either saturated-growth conditions or other stresses that cause prolonged inhibition of TORC1, which is a key integrator of growth signalling. Introns that become stabilized remain associated with components of the spliceosome and differ from other spliceosomal introns in having a short distance between their lariat branch point and 3' splice site, which is necessary and sufficient for their stabilization. Deletion of these unusual introns is disadvantageous in saturated conditions and causes aberrantly high growth rates in yeast that are chronically challenged with the TORC1 inhibitor rapamycin. The reintroduction of native or engineered stable introns suppresses this aberrant rapamycin response. Thus, excised introns function within the TOR growth-signalling network of S. cerevisiae and, more generally, excised spliceosomal introns can have biological functions." @default.
- W2952328530 created "2019-06-27" @default.
- W2952328530 creator A5013687539 @default.
- W2952328530 creator A5060182437 @default.
- W2952328530 creator A5087589263 @default.
- W2952328530 date "2019-01-01" @default.
- W2952328530 modified "2023-09-26" @default.
- W2952328530 title "Excised linear introns regulate growth in yeast" @default.
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- W2952328530 doi "https://doi.org/10.1038/s41586-018-0828-1" @default.
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- W2952328530 hasPublicationYear "2019" @default.
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