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- W2952329549 abstract "The CuH-catalyzed hydroamination of alkenes and alkynes using a silane and an amine transfer reagent represents a simple strategy to access chiral amine products. We have recently reported methods to prepare chiral amines with high efficiency and stereoselectivity using this approach. However, the current technology is limited to the synthesis of trialkylamines from dialkylamine transfer reagents (R2NOBz). When monoalkylamine transfer reagents [RN(H)OBz] were used for the synthesis of chiral secondary amines, competitive, nonproductive consumption of these reagents by the CuH species resulted in poor yields. In this paper, we report the design of a modified type of amine transfer reagent that addresses this limitation. This effort has enabled us to develop a CuH-catalyzed synthesis of chiral secondary amines using a variety of amine coupling partners, including those derived from amino acid esters, carbohydrates, and steroids. Mechanistic investigations indicated that the modified amine transfer reagents ..." @default.
- W2952329549 created "2019-06-27" @default.
- W2952329549 creator A5028652174 @default.
- W2952329549 creator A5039233288 @default.
- W2952329549 date "2015-11-01" @default.
- W2952329549 modified "2023-09-24" @default.
- W2952329549 title "ChemInform Abstract: Design of Modified Amine Transfer Reagents Allows the Synthesis of α-Chiral Secondary Amines via CuH-Catalyzed Hydroamination." @default.
- W2952329549 cites W2399980361 @default.
- W2952329549 doi "https://doi.org/10.1002/chin.201547041" @default.
- W2952329549 hasPublicationYear "2015" @default.
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