FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952334701> ?p ?o ?g. }

• W2952334701 endingPage "1373" @default.
• W2952334701 startingPage "1367" @default.
• W2952334701 abstract "While 3-hydroxybenzo[a]pyrene (3-OHBaP) is a preferable biomarker to assess human exposure to benzo[a]pyrene (BaP), a sensitive and simple method is lacking. In this study, a specific and sensitive method based on liquid chromatography coupled with electrospray tandem mass spectrometry (LC-ESI-MS/MS) was developed for direct analysis of 3-OHBaP glucuronide and sulfate conjugates in human urine samples without enzymatic hydrolysis. The limits of detection (LODs) were 0.06 ng L-1 for BaP-3-sulfate (BaP-3-S) and 0.16 ng L-1 for BaP-3-glucuronide (BaP-3-G), which showed high sensitivity. Both compounds showed excellent linearity (r2 > 0.99) in the range of 0.01-10 μg L-1 in the instrumental calibration. The absolute recoveries of the target analytes spiked in human urine for the entire analytical procedure were 68.3 ± 4.96% (mean ± SD) and 63.7 ± 5.47% for BaP-3-S and BaP-3-G, respectively. This method was applied to quantify BaP-3-G and BaP-3-S in 150 urine samples collected from healthy volunteers. The mean concentration of BaP-3-S was 0.67 ng g-1 creatinine (<LOD to 10.20 ng g-1 creatinine), about 10-fold lower than that of BaP-3-G (6.73 ng g-1 creatinine, < LOD to 52.64 ng g-1 creatinine). For comparison, we also detected the concentration of free 3-OHBaP in 15 randomly selected samples without enzymatic hydrolysis and found at least >98% of 3-OHBaP is excreted mainly in these two conjugated forms in human urine. A statistically significant positive association was observed between urinary 3-OHBaP conjugates and urinary 8-OHdG levels (p < 0.001) in the general population. This study developed a sensitive and simple method to determine urinary glucuronide/sulfate conjugated BaP metabolites and for the first time found that BaP exposure associated with 8-OHdG levels in the general population." @default.
• W2952334701 created "2019-06-27" @default.
• W2952334701 creator A5010492003 @default.
• W2952334701 creator A5055226928 @default.
• W2952334701 creator A5084711013 @default.
• W2952334701 date "2019-06-17" @default.
• W2952334701 modified "2023-10-10" @default.
• W2952334701 title "Determination of 3-Hydroxybenzo[a]pyrene Glucuronide/Sulfate Conjugates in Human Urine and Their Association with 8-Hydroxydeoxyguanosine" @default.
• W2952334701 cites W1974610463 @default.
• W2952334701 cites W1974765875 @default.
• W2952334701 cites W1981299725 @default.
• W2952334701 cites W1988418417 @default.
• W2952334701 cites W2008618763 @default.
• W2952334701 cites W2008846594 @default.
• W2952334701 cites W2009582193 @default.
• W2952334701 cites W2009896818 @default.
• W2952334701 cites W2011436989 @default.
• W2952334701 cites W2012150098 @default.
• W2952334701 cites W2020988697 @default.
• W2952334701 cites W2023669562 @default.
• W2952334701 cites W2024703652 @default.
• W2952334701 cites W2045931107 @default.
• W2952334701 cites W2048468348 @default.
• W2952334701 cites W2049451370 @default.
• W2952334701 cites W2049692921 @default.
• W2952334701 cites W2052089730 @default.
• W2952334701 cites W2062442493 @default.
• W2952334701 cites W2069014879 @default.
• W2952334701 cites W2070566044 @default.
• W2952334701 cites W2080519234 @default.
• W2952334701 cites W2083736606 @default.
• W2952334701 cites W2086551735 @default.
• W2952334701 cites W2087167264 @default.
• W2952334701 cites W2088814447 @default.
• W2952334701 cites W2090990681 @default.
• W2952334701 cites W2092567285 @default.
• W2952334701 cites W2093152101 @default.
• W2952334701 cites W2101324933 @default.
• W2952334701 cites W2111200869 @default.
• W2952334701 cites W2111617320 @default.
• W2952334701 cites W2137876021 @default.
• W2952334701 cites W2138131546 @default.
• W2952334701 cites W2143143891 @default.
• W2952334701 cites W2313617404 @default.
• W2952334701 cites W2318289300 @default.
• W2952334701 cites W2414415897 @default.
• W2952334701 cites W2585058487 @default.
• W2952334701 cites W2587429951 @default.
• W2952334701 cites W2587516812 @default.
• W2952334701 cites W2595051422 @default.
• W2952334701 cites W2618101080 @default.
• W2952334701 cites W2623019190 @default.
• W2952334701 cites W4256361068 @default.
• W2952334701 doi "https://doi.org/10.1021/acs.chemrestox.9b00025" @default.
• W2952334701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31204473" @default.
• W2952334701 hasPublicationYear "2019" @default.
• W2952334701 type Work @default.
• W2952334701 sameAs 2952334701 @default.
• W2952334701 citedByCount "10" @default.
• W2952334701 countsByYear W29523347012020 @default.
• W2952334701 countsByYear W29523347012021 @default.
• W2952334701 countsByYear W29523347012022 @default.
• W2952334701 countsByYear W29523347012023 @default.
• W2952334701 crossrefType "journal-article" @default.
• W2952334701 hasAuthorship W2952334701A5010492003 @default.
• W2952334701 hasAuthorship W2952334701A5055226928 @default.
• W2952334701 hasAuthorship W2952334701A5084711013 @default.
• W2952334701 hasConcept C119128265 @default.
• W2952334701 hasConcept C162356407 @default.
• W2952334701 hasConcept C178790620 @default.
• W2952334701 hasConcept C185592680 @default.
• W2952334701 hasConcept C2778951431 @default.
• W2952334701 hasConcept C2779186261 @default.
• W2952334701 hasConcept C2780026642 @default.
• W2952334701 hasConcept C2780306776 @default.
• W2952334701 hasConcept C31827203 @default.
• W2952334701 hasConcept C43617362 @default.
• W2952334701 hasConcept C53270655 @default.
• W2952334701 hasConcept C55493867 @default.
• W2952334701 hasConcept C94412978 @default.
• W2952334701 hasConceptScore W2952334701C119128265 @default.
• W2952334701 hasConceptScore W2952334701C162356407 @default.
• W2952334701 hasConceptScore W2952334701C178790620 @default.
• W2952334701 hasConceptScore W2952334701C185592680 @default.
• W2952334701 hasConceptScore W2952334701C2778951431 @default.
• W2952334701 hasConceptScore W2952334701C2779186261 @default.
• W2952334701 hasConceptScore W2952334701C2780026642 @default.
• W2952334701 hasConceptScore W2952334701C2780306776 @default.
• W2952334701 hasConceptScore W2952334701C31827203 @default.
• W2952334701 hasConceptScore W2952334701C43617362 @default.
• W2952334701 hasConceptScore W2952334701C53270655 @default.
• W2952334701 hasConceptScore W2952334701C55493867 @default.
• W2952334701 hasConceptScore W2952334701C94412978 @default.
• W2952334701 hasFunder F4320321001 @default.
• W2952334701 hasFunder F4320321540 @default.
• W2952334701 hasIssue "7" @default.
• W2952334701 hasLocation W29523347011 @default.
• W2952334701 hasLocation W29523347012 @default.

• next