Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952337149> ?p ?o ?g. }
- W2952337149 abstract "Neonatal brain damage and age-related neurodegenerative disease share many common mechanisms of injury involving mitochondriopathy, oxidative stress, excitotoxicity, inflammation, and neuronal cell death. We hypothesized that genes causing adult-onset neurodegeneration can influence acute outcome after CNS injury at immaturity and on the subsequent development of chronic disability after early-life brain injury. In two different transgenic (Tg) mouse models of adult-onset neurodegenerative disease, a human A53T-α-synuclein (hαSyn) model of Parkinson's disease (PD) and a human G93A-superoxide dismutase-1(hSOD1) model of amyotrophic lateral sclerosis (ALS), mortality and survivor morbidity were significantly greater than non-Tg mice and a Tg mouse model of Alzheimer's disease after neonatal traumatic brain injury (TBI). Acutely after brain injury, hαSyn neonatal mice showed a marked enhancement of protein oxidative damage in forebrain, brain regional mitochondrial oxidative metabolism, and mitochondriopathy. Extreme protein oxidative damage was also observed in neonatal mutant SOD1 mice after TBI. At 1 month of age, neuropathology in forebrain, midbrain, and brainstem of hαSyn mice with neonatal TBI was greater compared to sham hαSyn mice. Surviving hαSyn mice with TBI showed increased hαSyn aggregation and nitration and developed adult-onset disease months sooner and died earlier than non-injured hαSyn mice. Surviving hSOD1 mice with TBI also developed adult-onset disease and died sooner than non-injured hSOD1 mice. We conclude that mutant genes causing PD and ALS in humans have significant impact on mortality and morbidity after early-life brain injury and on age-related disease onset and proteinopathy in mice. This study provides novel insight into genetic determinants of poor outcomes after acute injury to the neonatal brain and how early-life brain injury can influence adult-onset neurodegenerative disease during aging." @default.
- W2952337149 created "2019-06-27" @default.
- W2952337149 creator A5024878520 @default.
- W2952337149 creator A5030774875 @default.
- W2952337149 creator A5088538875 @default.
- W2952337149 date "2019-06-18" @default.
- W2952337149 modified "2023-09-25" @default.
- W2952337149 title "Neonatal Brain Injury and Genetic Causes of Adult-Onset Neurodegenerative Disease in Mice Interact With Effects on Acute and Late Outcomes" @default.
- W2952337149 cites W1606105957 @default.
- W2952337149 cites W1966175599 @default.
- W2952337149 cites W1970283678 @default.
- W2952337149 cites W1971800584 @default.
- W2952337149 cites W1972260106 @default.
- W2952337149 cites W1972812522 @default.
- W2952337149 cites W1973319971 @default.
- W2952337149 cites W1975141413 @default.
- W2952337149 cites W1981182334 @default.
- W2952337149 cites W1981360487 @default.
- W2952337149 cites W1984326148 @default.
- W2952337149 cites W1990752558 @default.
- W2952337149 cites W1993023011 @default.
- W2952337149 cites W1994087800 @default.
- W2952337149 cites W1995426642 @default.
- W2952337149 cites W199574655 @default.
- W2952337149 cites W1997229283 @default.
- W2952337149 cites W2000149703 @default.
- W2952337149 cites W2001544013 @default.
- W2952337149 cites W2003892877 @default.
- W2952337149 cites W2008748100 @default.
- W2952337149 cites W2009556855 @default.
- W2952337149 cites W2015282923 @default.
- W2952337149 cites W2015424325 @default.
- W2952337149 cites W2027182042 @default.
- W2952337149 cites W2030715196 @default.
- W2952337149 cites W2031713384 @default.
- W2952337149 cites W2033360368 @default.
- W2952337149 cites W2045875853 @default.
- W2952337149 cites W2055361873 @default.
- W2952337149 cites W2057056489 @default.
- W2952337149 cites W2061995199 @default.
- W2952337149 cites W2066215889 @default.
- W2952337149 cites W2069632588 @default.
- W2952337149 cites W2074649216 @default.
- W2952337149 cites W2077024919 @default.
- W2952337149 cites W2078805667 @default.
- W2952337149 cites W2082429191 @default.
- W2952337149 cites W2083893372 @default.
- W2952337149 cites W2084910880 @default.
- W2952337149 cites W2090955970 @default.
- W2952337149 cites W2093343889 @default.
- W2952337149 cites W2093650784 @default.
- W2952337149 cites W2095146312 @default.
- W2952337149 cites W2097965815 @default.
- W2952337149 cites W2099565072 @default.
- W2952337149 cites W2099713982 @default.
- W2952337149 cites W2107768418 @default.
- W2952337149 cites W2111401548 @default.
- W2952337149 cites W2111855922 @default.
- W2952337149 cites W2112765817 @default.
- W2952337149 cites W2119092360 @default.
- W2952337149 cites W2123431154 @default.
- W2952337149 cites W2128332802 @default.
- W2952337149 cites W2131315270 @default.
- W2952337149 cites W2135970444 @default.
- W2952337149 cites W2136736966 @default.
- W2952337149 cites W2142483035 @default.
- W2952337149 cites W2147220169 @default.
- W2952337149 cites W2150656456 @default.
- W2952337149 cites W2152476219 @default.
- W2952337149 cites W2161334375 @default.
- W2952337149 cites W2169604722 @default.
- W2952337149 cites W2197519625 @default.
- W2952337149 cites W2202636361 @default.
- W2952337149 cites W2318368094 @default.
- W2952337149 cites W2328705360 @default.
- W2952337149 cites W2332469551 @default.
- W2952337149 cites W2346143475 @default.
- W2952337149 cites W2417377240 @default.
- W2952337149 cites W2464966002 @default.
- W2952337149 cites W2474295863 @default.
- W2952337149 cites W2544617189 @default.
- W2952337149 cites W2587817530 @default.
- W2952337149 cites W2593046780 @default.
- W2952337149 cites W2734763051 @default.
- W2952337149 cites W2791211012 @default.
- W2952337149 cites W2804641178 @default.
- W2952337149 cites W2884104985 @default.
- W2952337149 cites W2889199320 @default.
- W2952337149 doi "https://doi.org/10.3389/fneur.2019.00635" @default.
- W2952337149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6591316" @default.
- W2952337149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31275228" @default.
- W2952337149 hasPublicationYear "2019" @default.
- W2952337149 type Work @default.
- W2952337149 sameAs 2952337149 @default.
- W2952337149 citedByCount "5" @default.
- W2952337149 countsByYear W29523371492020 @default.
- W2952337149 countsByYear W29523371492021 @default.
- W2952337149 countsByYear W29523371492023 @default.
- W2952337149 crossrefType "journal-article" @default.
- W2952337149 hasAuthorship W2952337149A5024878520 @default.