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- W2952348907 abstract "Abstract Natural biochemical systems are ubiquitously organized both in space and time. Engineering the spatial organization of biochemistry has emerged as a key theme of synthetic biology, with numerous technologies promising improved biosynthetic pathway performance. One strategy, however, may produce disparate results for different biosynthetic pathways. We propose a spatially resolved kinetic model to explore this fundamental design choice in systems and synthetic biology. We predict that two example biosynthetic pathways have distinct optimal organization strategies that vary based on pathway-dependent and cell-extrinsic factors. Moreover, we outline this design space in general as a function of kinetic and biophysical properties, as well as culture conditions. Our results suggest that organizing biosynthesis has the potential to substantially improve performance, but that choosing the appropriate strategy is key. The flexible mathematical framework we propose can be adapted to diverse biosynthetic pathways, and lays a foundation to rationally choose organization strategies for biosynthesis." @default.
- W2952348907 created "2019-06-27" @default.
- W2952348907 creator A5061441403 @default.
- W2952348907 creator A5075689223 @default.
- W2952348907 creator A5075972178 @default.
- W2952348907 date "2017-10-12" @default.
- W2952348907 modified "2023-10-18" @default.
- W2952348907 title "Spatially organizing biochemistry: choosing a strategy to translate synthetic biology to the factory" @default.
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- W2952348907 doi "https://doi.org/10.1101/202259" @default.
- W2952348907 hasPublicationYear "2017" @default.
- W2952348907 type Work @default.
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