Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952348973> ?p ?o ?g. }
- W2952348973 abstract "Acromegaly is a rare disease with an increased morbidity and mortality predominantly due to cardiovascular diseases. In this review we examined the relationship between GH/IGF-1 excess and endothelium, from basic studies to clinical evidences. Many studies involving various arterial district (microvascular arteries of retina, kidney and brain, and major vessels as carotid and aorta) showed that GH/IGF-1 excess promotes endothelial dysfunction by several mechanisms. Increased endothelial proliferation, dysfunction of endothelial progenitor cells, increased oxidative stress and decreased oxidative defences are the main factors that are associated to endothelial dysfunction. In general population these alterations are associated to the development of atherosclerosis with an increased incidence of coronary artery and cerebral disease, but in acromegaly this is still a debated issue, despite the presence of many pro-atherogenic factors and comorbidities (hypertension, diabetes, sleep apnoea, metabolic syndrome). Preclinical markers of atherosclerosis such as arterial intima media thickness, pulse wave velocity and flow mediated dilation seems to be impaired in acromegaly. In addition, some studies analysed microcirculation in acromegaly reporting discordant results: in general population impairment of microcirculation is associated with an increased risk of cardiovascular disease so it would be important define its effective role in acromegaly. In conclusion, pathophysiology of endothelium dysfunction and the association to cardiovascular disease are not fully understood in acromegaly: further studies on this complex area are so necessary." @default.
- W2952348973 created "2019-06-27" @default.
- W2952348973 creator A5019758629 @default.
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- W2952348973 creator A5051403646 @default.
- W2952348973 date "2019-07-24" @default.
- W2952348973 modified "2023-10-17" @default.
- W2952348973 title "The Endothelium in Acromegaly" @default.
- W2952348973 cites W140667287 @default.
- W2952348973 cites W1588436096 @default.
- W2952348973 cites W1605687369 @default.
- W2952348973 cites W170621466 @default.
- W2952348973 cites W1803374268 @default.
- W2952348973 cites W1849714433 @default.
- W2952348973 cites W1965010628 @default.
- W2952348973 cites W1965920988 @default.
- W2952348973 cites W1966131659 @default.
- W2952348973 cites W1966591915 @default.
- W2952348973 cites W1966787584 @default.
- W2952348973 cites W1968235589 @default.
- W2952348973 cites W1969119140 @default.
- W2952348973 cites W1971435116 @default.
- W2952348973 cites W1972655090 @default.
- W2952348973 cites W1975295224 @default.
- W2952348973 cites W1976215223 @default.
- W2952348973 cites W1976578183 @default.
- W2952348973 cites W1978746698 @default.
- W2952348973 cites W1979416346 @default.
- W2952348973 cites W1982892945 @default.
- W2952348973 cites W1984097105 @default.
- W2952348973 cites W1985431943 @default.
- W2952348973 cites W1986592250 @default.
- W2952348973 cites W1988256002 @default.
- W2952348973 cites W1991041813 @default.
- W2952348973 cites W1994796884 @default.
- W2952348973 cites W1995025073 @default.
- W2952348973 cites W1995802581 @default.
- W2952348973 cites W2000534182 @default.
- W2952348973 cites W2000593961 @default.
- W2952348973 cites W2002070825 @default.
- W2952348973 cites W2003269305 @default.
- W2952348973 cites W2004291026 @default.
- W2952348973 cites W2004585879 @default.
- W2952348973 cites W2007994057 @default.
- W2952348973 cites W2009189358 @default.
- W2952348973 cites W2009598457 @default.
- W2952348973 cites W2009977850 @default.
- W2952348973 cites W2010288774 @default.
- W2952348973 cites W2011638589 @default.
- W2952348973 cites W2014281571 @default.
- W2952348973 cites W2016742796 @default.
- W2952348973 cites W2017103521 @default.
- W2952348973 cites W2020342072 @default.
- W2952348973 cites W2021410503 @default.
- W2952348973 cites W2022770339 @default.
- W2952348973 cites W2023220864 @default.
- W2952348973 cites W2023353015 @default.
- W2952348973 cites W2026178066 @default.
- W2952348973 cites W2026944375 @default.
- W2952348973 cites W2030504628 @default.
- W2952348973 cites W2031434686 @default.
- W2952348973 cites W2032679049 @default.
- W2952348973 cites W2038792379 @default.
- W2952348973 cites W2039567324 @default.
- W2952348973 cites W2039792609 @default.
- W2952348973 cites W2039996525 @default.
- W2952348973 cites W2043451798 @default.
- W2952348973 cites W2046724915 @default.
- W2952348973 cites W2047479767 @default.
- W2952348973 cites W2047575999 @default.
- W2952348973 cites W2047894422 @default.
- W2952348973 cites W2049832705 @default.
- W2952348973 cites W2050415900 @default.
- W2952348973 cites W2052481087 @default.
- W2952348973 cites W2054024601 @default.
- W2952348973 cites W2057177141 @default.
- W2952348973 cites W2058560205 @default.
- W2952348973 cites W2058720714 @default.
- W2952348973 cites W2060385751 @default.
- W2952348973 cites W2062205498 @default.
- W2952348973 cites W2063449352 @default.
- W2952348973 cites W2063506869 @default.
- W2952348973 cites W2063998910 @default.
- W2952348973 cites W2067345612 @default.
- W2952348973 cites W2068198239 @default.
- W2952348973 cites W2068382689 @default.
- W2952348973 cites W2069668711 @default.
- W2952348973 cites W2071672848 @default.
- W2952348973 cites W2072099192 @default.
- W2952348973 cites W2072470670 @default.
- W2952348973 cites W2075740688 @default.
- W2952348973 cites W2079251878 @default.
- W2952348973 cites W2081419267 @default.
- W2952348973 cites W2082596521 @default.
- W2952348973 cites W2083624909 @default.
- W2952348973 cites W2089980640 @default.
- W2952348973 cites W2091440592 @default.
- W2952348973 cites W2091531652 @default.