Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952355463> ?p ?o ?g. }
- W2952355463 endingPage "849" @default.
- W2952355463 startingPage "849" @default.
- W2952355463 abstract "Factors involved in the spontaneous cleareance of a hepatitis C (HCV) infection are related to both HCV and the interaction with the host immune system, but little is known about the consequences after a spontaneous resolution. The main HCV extrahepatic reservoir is the peripheral blood mononuclear cells (PBMCs), and their transcriptional profile provides us information of innate and adaptive immune responses against an HCV infection. MicroRNAs regulate the innate and adaptive immune responses, and they are actively involved in the HCV cycle. High Throughput sequencing was used to analyze the miRNA profiles from PBMCs of HCV chronic naïve patients (CHC), individuals that spontaneously clarified HCV (SC), and healthy controls (HC). We did not find any differentially expressed miRNAs between SC and CHC. However, both groups showed similar expression differences (21 miRNAs) with respect to HC. This miRNA signature correctly classifies HCV-exposed (CHC and SC) vs. HC, with the has-miR-21-3p showing the best performance. The potentially targeted molecular pathways by these 21 miRNAs mainly belong to fatty acids pathways, although hippo signaling, extracellular matrix (ECM) interaction, proteoglycans-related, and steroid biosynthesis pathways were also altered. These miRNAs target host genes involved in an HCV infection. Thus, an HCV infection promotes molecular alterations in PBMCs that can be detected after an HCV spontaneous resolution, and the 21-miRNA signature is able to identify HCV-exposed patients (either CHC or SC)." @default.
- W2952355463 created "2019-06-27" @default.
- W2952355463 creator A5007361658 @default.
- W2952355463 creator A5008229565 @default.
- W2952355463 creator A5013551077 @default.
- W2952355463 creator A5014766542 @default.
- W2952355463 creator A5015974810 @default.
- W2952355463 creator A5016598680 @default.
- W2952355463 creator A5025442218 @default.
- W2952355463 creator A5027027591 @default.
- W2952355463 creator A5028677580 @default.
- W2952355463 creator A5037607853 @default.
- W2952355463 creator A5057463160 @default.
- W2952355463 creator A5064746631 @default.
- W2952355463 creator A5065624460 @default.
- W2952355463 creator A5075989300 @default.
- W2952355463 creator A5079952452 @default.
- W2952355463 creator A5084472966 @default.
- W2952355463 creator A5084846308 @default.
- W2952355463 date "2019-06-14" @default.
- W2952355463 modified "2023-10-18" @default.
- W2952355463 title "MicroRNA Profile of HCV Spontaneous Clarified Individuals, Denotes Previous HCV Infection" @default.
- W2952355463 cites W1505139021 @default.
- W2952355463 cites W1579850989 @default.
- W2952355463 cites W1640847094 @default.
- W2952355463 cites W183409258 @default.
- W2952355463 cites W1878417189 @default.
- W2952355463 cites W1964007959 @default.
- W2952355463 cites W1965149500 @default.
- W2952355463 cites W1965396914 @default.
- W2952355463 cites W1983793392 @default.
- W2952355463 cites W1987836966 @default.
- W2952355463 cites W1993165035 @default.
- W2952355463 cites W1996181208 @default.
- W2952355463 cites W2001428704 @default.
- W2952355463 cites W2005692869 @default.
- W2952355463 cites W2006548076 @default.
- W2952355463 cites W2009663348 @default.
- W2952355463 cites W2018627773 @default.
- W2952355463 cites W2025124945 @default.
- W2952355463 cites W2025994588 @default.
- W2952355463 cites W2030317825 @default.
- W2952355463 cites W2030608722 @default.
- W2952355463 cites W2034851420 @default.
- W2952355463 cites W2054270408 @default.
- W2952355463 cites W2056577175 @default.
- W2952355463 cites W2057777065 @default.
- W2952355463 cites W2069095633 @default.
- W2952355463 cites W2070494252 @default.
- W2952355463 cites W2072445922 @default.
- W2952355463 cites W2099216998 @default.
- W2952355463 cites W2099517096 @default.
- W2952355463 cites W2105136471 @default.
- W2952355463 cites W2110173009 @default.
- W2952355463 cites W2114741516 @default.
- W2952355463 cites W2121249810 @default.
- W2952355463 cites W2125178521 @default.
- W2952355463 cites W2136274799 @default.
- W2952355463 cites W2137417346 @default.
- W2952355463 cites W2143237382 @default.
- W2952355463 cites W2147437748 @default.
- W2952355463 cites W2153863419 @default.
- W2952355463 cites W2154702145 @default.
- W2952355463 cites W2165362629 @default.
- W2952355463 cites W2167250060 @default.
- W2952355463 cites W2221465314 @default.
- W2952355463 cites W2259167207 @default.
- W2952355463 cites W2285118397 @default.
- W2952355463 cites W2298812434 @default.
- W2952355463 cites W2400129967 @default.
- W2952355463 cites W2401657071 @default.
- W2952355463 cites W2407917947 @default.
- W2952355463 cites W2514140875 @default.
- W2952355463 cites W2514905230 @default.
- W2952355463 cites W2516081867 @default.
- W2952355463 cites W2519616424 @default.
- W2952355463 cites W2539235504 @default.
- W2952355463 cites W2560785983 @default.
- W2952355463 cites W2595963502 @default.
- W2952355463 cites W2695809411 @default.
- W2952355463 cites W2740711856 @default.
- W2952355463 cites W2766318992 @default.
- W2952355463 cites W2767606769 @default.
- W2952355463 cites W2769874263 @default.
- W2952355463 cites W2776332611 @default.
- W2952355463 cites W2787502694 @default.
- W2952355463 cites W2789885586 @default.
- W2952355463 cites W2790339633 @default.
- W2952355463 cites W2794799252 @default.
- W2952355463 cites W2803981438 @default.
- W2952355463 cites W2806732960 @default.
- W2952355463 cites W2806806917 @default.
- W2952355463 cites W2807326971 @default.
- W2952355463 cites W2887489400 @default.
- W2952355463 cites W2892324919 @default.
- W2952355463 cites W2895830059 @default.
- W2952355463 cites W2901951586 @default.
- W2952355463 doi "https://doi.org/10.3390/jcm8060849" @default.