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- W2952362824 abstract "1, 6-Dihydro-6-oxo-2-pyrazinecarboxylic acid 4-oxide (1) has been synthesized by two different methods. The first is a hydrolysis of methyl 6-chloro-2-pyrazinecarboxylate 4-oxide, which was in turn obtained from methyl 6-chloro-2-pyrazinecarboxylate by reaction with m-chloroperbenzoic acid. The second is an oxidation of 6-hydroxymethyl-2 (1H)-pyrazinone 4-oxide with nickel peroxide. Compound 1 was converted to amine salts, esters and amides. 6-Methoxy, 6-mercapto and 1-alkyl derivatives were also prepared. The compounds prepared were tested for anticoccidial activity in chickens against Eimeria tenella and marked activity was seen with compound 1 and amine salts of 1. The activity of 1 was counteracted by the simultaneous administration of an equal weight of orotic acid or adenine." @default.
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- W2952362824 date "1981-06-23" @default.
- W2952362824 modified "2023-09-24" @default.
- W2952362824 title "ChemInform Abstract: ANTICOCCIDIALS. VI. AN IMPROVED SYNTHESIS OF 1,6-DIHYDRO-6-OXO-2-PYRAZINECARBOXYLIC ACID 4-OXIDE AND SOME RELATED DERIVATIVES AND DETERMINATION OF ANTICOCCIDIAL ACTIVITY" @default.
- W2952362824 cites W1490294489 @default.
- W2952362824 doi "https://doi.org/10.1002/chin.198125261" @default.
- W2952362824 hasPublicationYear "1981" @default.
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