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- W2952365313 abstract "Abstract Macrophages protect the body from damage and disease by targeting antibody-opsonized cells for phagocytosis. Though antibodies can be raised against antigens with diverse structures, shapes, and sizes, it is unclear why some are more effective at triggering antibody-dependent phagocytosis than others. Here we quantitatively define an antigen height threshold that regulates phagocytosis of both engineered and cancer-specific antigens by macrophages. Using a reconstituted model of antibody-opsonized target cells, we find that phagocytosis is dramatically impaired for antigens that position antibodies >10 nm from the target surface. Increasing antigen height allows for co-localization of Fc receptors and the inhibitory phosphatase CD45 at the cell-cell interface, which reduces Fc receptor phosphorylation, and inhibits phagocytosis. Our work shows that close contact between macrophage and target cell is a requirement for efficient phagocytosis, suggesting that therapeutic antibodies should target short antigens in order to trigger Fc receptor activation through size-dependent physical segregation." @default.
- W2952365313 created "2019-06-27" @default.
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- W2952365313 date "2018-01-19" @default.
- W2952365313 modified "2023-09-28" @default.
- W2952365313 title "Size-dependent segregation controls macrophage phagocytosis of antibody-opsonized targets" @default.
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- W2952365313 doi "https://doi.org/10.1101/250373" @default.
- W2952365313 hasPublicationYear "2018" @default.
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