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- W2952373769 abstract "Background: Gallbladder carcinoma is a rare malignancy, which carries a poor prognosis. Radical cholecystectomy is considered the treatment of choice for most resectable gallbladder carcinoma. Methods: We retrospectively analyzed all patients who underwent surgical resection with curative intent for gallbladder carcinoma in our institution from 2007 to 2017. Patients with non-metastatic nor node involving disease greater than T1a were included. We compared clinical and oncological outcomes of patients who underwent Radical cholecystectomy compared to simple cholecystectomy. Results: Overall 30 patients with GBC T stage Ib,II,IIIa (N0M0) underwent simple cholecystectomy. We matched a group of 33 patients underwent Radical cholecystectomy who had comparable variables. Age (mean, years, 70 vs. 66), gender (female, %, 60 vs. 76), ASA score (%) (I – 11 vs. 30, II – 39 vs. 40, III 32 vs. 24, IV – 18 vs. 6), TNM stage (%, T1b – 30 vs. 18, T2 – 53 vs. 67, T3 – 17 vs. 15), surgical approach (laparoscopic, %, 70 vs. 54) and adjuvant therapy (%, 21 vs. 27) were all comparable (p = NS). As would be expected, incidental finding was significantly lower for those who underwent RC (%, 83 vs. 61, p = 0.05), although the gallbladder carcinoma was incidentally found in the majority of patients in both groups. Tumor maximal dimension was significantly different between groups (mean, mm, 18 vs. 32, p = 0.01). At median follow-up of 29 months, 26 patients recurred. Mean disease-free survival was 19 vs. 29 months (p = 0.85), and overall survival was 22 vs. 32 months (p = 0.38). Conclusion: In this small analysis of stage matched patients with gallbladder carcinoma with node negative disease there was no statistically significant difference in overall survival or disease free survival. Simple cholecystectomy may be considered definitive therapy in patients with advanced age or poor performance status." @default.
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- W2952373769 date "2019-03-01" @default.
- W2952373769 modified "2023-09-27" @default.
- W2952373769 title "Simple cholecystectomy for T1b and greater node negative non metastatic gallbladder carcinoma" @default.
- W2952373769 doi "https://doi.org/10.1016/j.hpb.2019.03.294" @default.
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