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- W2952392477 abstract "We propose a numerical technique for parameter inference in Markov models of biological processes. Based on time-series data of a process we estimate the kinetic rate constants by maximizing the likelihood of the data. The computation of the likelihood relies on a dynamic abstraction of the discrete state space of the Markov model which successfully mitigates the problem of state space largeness. We compare two variants of our method to state-of-the-art, recently published methods and demonstrate their usefulness and efficiency on several case studies from systems biology." @default.
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- W2952392477 date "2011-02-14" @default.
- W2952392477 modified "2023-09-27" @default.
- W2952392477 title "Parameter Identification for Markov Models of Biochemical Reactions" @default.
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