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- W2952400570 abstract "Abstract Multiple myeloma is a malignancy of antibody-secreting plasma cells. Most patients benefit from current therapies, however, 20% of patients relapse or die within two years and are deemed high risk. Here we analyze structural variants from 795 newly-diagnosed patients as part of the CoMMpass study. We report translocations involving the immunoglobulin lambda (IgL) locus are present in 10% of patients, and indicative of poor prognosis. This is particularly true for IgL-MYC translocations, which coincide with focal amplifications of enhancers at both loci. Importantly, 78% of IgL-MYC translocations co-occur with hyperdiploid disease, a marker of standard risk, suggesting that IgL-MYC-translocated myeloma is being misclassified. Patients with IgL-translocations fail to benefit from IMiDs, which target IKZF1, a transcription factor that binds the IgL enhancer at some of the highest levels in the myeloma epigenome. These data implicate IgL translocation as a driver of poor prognosis which may be due to IMiD resistance." @default.
- W2952400570 created "2019-06-27" @default.
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- W2952400570 date "2019-04-23" @default.
- W2952400570 modified "2023-10-17" @default.
- W2952400570 title "Multiple myeloma immunoglobulin lambda translocations portend poor prognosis" @default.
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- W2952400570 doi "https://doi.org/10.1038/s41467-019-09555-6" @default.
- W2952400570 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6478743" @default.
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