Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952407343> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2952407343 endingPage "1289" @default.
- W2952407343 startingPage "1284" @default.
- W2952407343 abstract "Abstract To detect doping with endogenous steroids, six urinary steroids are longitudinally monitored in the athlete biological passport (ABP). These steroids include testosterone, etiocholanolone, androsterone, 5α‐androstane‐3α,17β‐diol, 5β‐androstane‐3α,17β‐diol, and the testosterone isomer epitestosterone. It is known that the intake of hormonal contraceptives may interfere with the ABP biomarkers. A previous study showed that athletes using hormonal contraceptives (HCs) display lower urinary epitestosterone concentrations than non‐using athletes. In this study, we analyzed the urinary steroid profile prior to and three months after administration of an oral HC including levonorgestrel and ethinylestradiol ( n = 55). The urinary concentrations of all the ABP metabolites decreased after three months, with epitestosterone showing the largest decline (median 6.78 to 3.04 ng/mL, p˂0.0001) followed by 5α‐androstane‐3α,17β‐diol (median 23.5 to 12.83 ng/mL, p˂0.0001), and testosterone (median 5.32 to 3.66, p˂0.0001). Epitestosterone is included in two of the five ratios in the ABP (T/E and 5αAdiol/E), and consequently these ratios increased 1.7‐fold (range 0.27 to 8.50) and 1.26‐fold (range 0.14 to 5.91), respectively. Some of these changes may mimic the changes seen after administration of endogenous steroids leading to atypical findings. Notably, even though participants used the same contraceptive treatment schedule, the HC‐mediated epitestosterone change varied to a large extent (median 0.43‐fold, range 0.06 to 6.5) and were associated with a functional T˃C promoter polymorphism in CYP17A1 . Moreover, the epitestosterone changes correlated with HC‐induced testosterone and gonadotropins changes in serum, indicating that urinary epitestosterone reflects the androgen load in HC‐using women." @default.
- W2952407343 created "2019-06-27" @default.
- W2952407343 creator A5002698687 @default.
- W2952407343 creator A5026868555 @default.
- W2952407343 creator A5033369161 @default.
- W2952407343 creator A5053216955 @default.
- W2952407343 creator A5060335521 @default.
- W2952407343 date "2019-07-17" @default.
- W2952407343 modified "2023-10-10" @default.
- W2952407343 title "Impact of hormonal contraceptives on urinary steroid profile in relation to serum hormone changes and CYP17A1 polymorphism" @default.
- W2952407343 cites W1570869330 @default.
- W2952407343 cites W1984196537 @default.
- W2952407343 cites W2026181076 @default.
- W2952407343 cites W2027308470 @default.
- W2952407343 cites W2067432290 @default.
- W2952407343 cites W2071641996 @default.
- W2952407343 cites W2087422536 @default.
- W2952407343 cites W2097846180 @default.
- W2952407343 cites W2106983444 @default.
- W2952407343 cites W2116031303 @default.
- W2952407343 cites W2122772347 @default.
- W2952407343 cites W2514175137 @default.
- W2952407343 cites W2529109369 @default.
- W2952407343 cites W2538667855 @default.
- W2952407343 cites W2769101301 @default.
- W2952407343 doi "https://doi.org/10.1002/dta.2663" @default.
- W2952407343 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31207124" @default.
- W2952407343 hasPublicationYear "2019" @default.
- W2952407343 type Work @default.
- W2952407343 sameAs 2952407343 @default.
- W2952407343 citedByCount "11" @default.
- W2952407343 countsByYear W29524073432020 @default.
- W2952407343 countsByYear W29524073432021 @default.
- W2952407343 countsByYear W29524073432022 @default.
- W2952407343 countsByYear W29524073432023 @default.
- W2952407343 crossrefType "journal-article" @default.
- W2952407343 hasAuthorship W2952407343A5002698687 @default.
- W2952407343 hasAuthorship W2952407343A5026868555 @default.
- W2952407343 hasAuthorship W2952407343A5033369161 @default.
- W2952407343 hasAuthorship W2952407343A5053216955 @default.
- W2952407343 hasAuthorship W2952407343A5060335521 @default.
- W2952407343 hasConcept C126322002 @default.
- W2952407343 hasConcept C134018914 @default.
- W2952407343 hasConcept C185592680 @default.
- W2952407343 hasConcept C2777344897 @default.
- W2952407343 hasConcept C2777911890 @default.
- W2952407343 hasConcept C2777956591 @default.
- W2952407343 hasConcept C2779279991 @default.
- W2952407343 hasConcept C2779341496 @default.
- W2952407343 hasConcept C2779746161 @default.
- W2952407343 hasConcept C2780902042 @default.
- W2952407343 hasConcept C2908647359 @default.
- W2952407343 hasConcept C2986817661 @default.
- W2952407343 hasConcept C71315377 @default.
- W2952407343 hasConcept C71924100 @default.
- W2952407343 hasConcept C77411442 @default.
- W2952407343 hasConcept C99454951 @default.
- W2952407343 hasConceptScore W2952407343C126322002 @default.
- W2952407343 hasConceptScore W2952407343C134018914 @default.
- W2952407343 hasConceptScore W2952407343C185592680 @default.
- W2952407343 hasConceptScore W2952407343C2777344897 @default.
- W2952407343 hasConceptScore W2952407343C2777911890 @default.
- W2952407343 hasConceptScore W2952407343C2777956591 @default.
- W2952407343 hasConceptScore W2952407343C2779279991 @default.
- W2952407343 hasConceptScore W2952407343C2779341496 @default.
- W2952407343 hasConceptScore W2952407343C2779746161 @default.
- W2952407343 hasConceptScore W2952407343C2780902042 @default.
- W2952407343 hasConceptScore W2952407343C2908647359 @default.
- W2952407343 hasConceptScore W2952407343C2986817661 @default.
- W2952407343 hasConceptScore W2952407343C71315377 @default.
- W2952407343 hasConceptScore W2952407343C71924100 @default.
- W2952407343 hasConceptScore W2952407343C77411442 @default.
- W2952407343 hasConceptScore W2952407343C99454951 @default.
- W2952407343 hasFunder F4320323245 @default.
- W2952407343 hasIssue "9" @default.
- W2952407343 hasLocation W29524073431 @default.
- W2952407343 hasLocation W29524073432 @default.
- W2952407343 hasOpenAccess W2952407343 @default.
- W2952407343 hasPrimaryLocation W29524073431 @default.
- W2952407343 hasRelatedWork W2014310809 @default.
- W2952407343 hasRelatedWork W2044678541 @default.
- W2952407343 hasRelatedWork W2060626799 @default.
- W2952407343 hasRelatedWork W2095843048 @default.
- W2952407343 hasRelatedWork W2181958518 @default.
- W2952407343 hasRelatedWork W2333904811 @default.
- W2952407343 hasRelatedWork W2368898247 @default.
- W2952407343 hasRelatedWork W2423790779 @default.
- W2952407343 hasRelatedWork W3005343690 @default.
- W2952407343 hasRelatedWork W2466762159 @default.
- W2952407343 hasVolume "11" @default.
- W2952407343 isParatext "false" @default.
- W2952407343 isRetracted "false" @default.
- W2952407343 magId "2952407343" @default.
- W2952407343 workType "article" @default.