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- W2952408521 abstract "Abstract The synthesis of phosphate ester derivatives of AZT with tethered N,N,N′trimethylethylenediamine, N-methylpiperazine and 2,6-diacetyl pyridine as prodrugs of AZT with potential ribonuclease activity was described. The metal complexes of these compounds should combine a reverse transcriptase inhibition and the ability to hydrolyze the RNA of HIV. Different phosphorus chemistries have been used to synthetize phosphodiesters. The synthesis of phosphotriesters was achieved by a nucleophilic displacement of the halogeno moieties by an activated phosphodiester in one or two chemical steps. The copper complexes of N,N,N′trimethylethylenediamine derivatives were fully characterized and their ribonuclease activity toward 25-mer and 28-mer oligoribonucleotides was demonstrated by capillary electrophoresis. The in vitro anti HIV preliminary assays revealed no synergistic effect with copper chelate on the activity of the prodrugs." @default.
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- W2952408521 date "1995-06-01" @default.
- W2952408521 modified "2023-09-25" @default.
- W2952408521 title "Synthesis and properties of phosphodiester and triester derivatives of AZT with tethered potential ribonucleases" @default.
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- W2952408521 doi "https://doi.org/10.1016/0040-4020(95)00320-8" @default.
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