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- W2952422013 abstract "A practical synthetic route to 4-acetylisocoumarins and the first total synthesis of AGI-7 (5) and sescandelin (4) are described. The readily available homophthalate 8 was transformed to the vinylogous amide ester 13 in high overall yield. Upon treatment of 13 with refluxing aqueous formic acid, the desired 4-acetylisocoumarin (5) and its regioisomer 3-methyl-4-formylisocoumarin (17) were produced in a 3:1 ratio. After separation of the desired product (5) from the unwanted minor isomer, the enantioselective reduction of AGI-7 by borane in the presence of Corey's (S)-oxazaborolidine reagent afforded (+)-sescandelin (4) with a 93% ee." @default.
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- W2952422013 date "2002-03-29" @default.
- W2952422013 modified "2023-10-13" @default.
- W2952422013 title "Synthesis of 4-Acetylisocoumarin: First Total Syntheses of AGI-7 and Sescandelin" @default.
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- W2952422013 doi "https://doi.org/10.1021/jo010789b" @default.
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