FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952429284> ?p ?o ?g. }

• W2952429284 endingPage "808" @default.
• W2952429284 startingPage "794" @default.
• W2952429284 abstract "Recent advances in research on gene drives have produced genetic constructs that could theoretically spread a desired gene (payload) into all populations of a species, with a single release in one place. This attribute has advantages, but also comes with risks and ethical concerns. There has been a call for research on gene drive systems that are spatially and/or temporally self-limiting. Here, we use a population genetics model to compare the expected characteristics of three spatially self-limiting gene drive systems: one-locus underdominance, two-locus underdominance and daisy-chain drives. We find large differences between these gene drives in the minimum release size required for successfully driving a payload into a population. The daisy-chain system is the most efficient, requiring the smallest release, followed by the two-locus underdominance system, and then the one-locus underdominance system. However, when the target population exchanges migrants with a nontarget population, the gene drives requiring smaller releases suffer from higher risks of unintended spread. For payloads that incur relatively low fitness costs (up to 30%), a simple daisy-chain drive is practically incapable of remaining localized, even with migration rates as low as 0.5% per generation. The two-locus underdominance system can achieve localized spread under a broader range of migration rates and of payload fitness costs, while the one-locus underdominance system largely remains localized. We also find differences in the extent of population alteration and in the permanence of the alteration achieved by the three gene drives. The two-locus underdominance system does not always spread the payload to fixation, even after successful drive, while the daisy-chain system can, for a small set of parameter values, achieve a temporally limited spread of the payload. These differences could affect the suitability of each gene drive for specific applications." @default.
• W2952429284 created "2019-06-27" @default.
• W2952429284 creator A5004001756 @default.
• W2952429284 creator A5042313556 @default.
• W2952429284 creator A5050973347 @default.
• W2952429284 creator A5078108136 @default.
• W2952429284 date "2018-01-04" @default.
• W2952429284 modified "2023-10-12" @default.
• W2952429284 title "Invasion and migration of spatially self‐limiting gene drives: A comparative analysis" @default.
• W2952429284 cites W1836619290 @default.
• W2952429284 cites W1965747854 @default.
• W2952429284 cites W1982287802 @default.
• W2952429284 cites W1987327670 @default.
• W2952429284 cites W1998312410 @default.
• W2952429284 cites W1999828194 @default.
• W2952429284 cites W2024329194 @default.
• W2952429284 cites W2046038163 @default.
• W2952429284 cites W2051088451 @default.
• W2952429284 cites W2072404542 @default.
• W2952429284 cites W2087475552 @default.
• W2952429284 cites W2090881966 @default.
• W2952429284 cites W2107817332 @default.
• W2952429284 cites W2109838045 @default.
• W2952429284 cites W2112108979 @default.
• W2952429284 cites W2122404497 @default.
• W2952429284 cites W2127812211 @default.
• W2952429284 cites W2135945061 @default.
• W2952429284 cites W2138074610 @default.
• W2952429284 cites W2144134062 @default.
• W2952429284 cites W2155125788 @default.
• W2952429284 cites W2160885698 @default.
• W2952429284 cites W2171085752 @default.
• W2952429284 cites W2180866616 @default.
• W2952429284 cites W2190054909 @default.
• W2952429284 cites W2496948780 @default.
• W2952429284 cites W2542460418 @default.
• W2952429284 cites W2584840797 @default.
• W2952429284 cites W2589423646 @default.
• W2952429284 cites W2594079799 @default.
• W2952429284 cites W2734771417 @default.
• W2952429284 cites W2949144539 @default.
• W2952429284 cites W2949834184 @default.
• W2952429284 cites W2950208551 @default.
• W2952429284 cites W2950981781 @default.
• W2952429284 cites W2952506845 @default.
• W2952429284 cites W2952712887 @default.
• W2952429284 cites W4245442151 @default.
• W2952429284 doi "https://doi.org/10.1111/eva.12583" @default.
• W2952429284 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5978947" @default.
• W2952429284 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29875820" @default.
• W2952429284 hasPublicationYear "2018" @default.
• W2952429284 type Work @default.
• W2952429284 sameAs 2952429284 @default.
• W2952429284 citedByCount "91" @default.
• W2952429284 countsByYear W29524292842018 @default.
• W2952429284 countsByYear W29524292842019 @default.
• W2952429284 countsByYear W29524292842020 @default.
• W2952429284 countsByYear W29524292842021 @default.
• W2952429284 countsByYear W29524292842022 @default.
• W2952429284 countsByYear W29524292842023 @default.
• W2952429284 crossrefType "journal-article" @default.
• W2952429284 hasAuthorship W2952429284A5004001756 @default.
• W2952429284 hasAuthorship W2952429284A5042313556 @default.
• W2952429284 hasAuthorship W2952429284A5050973347 @default.
• W2952429284 hasAuthorship W2952429284A5078108136 @default.
• W2952429284 hasBestOaLocation W29524292841 @default.
• W2952429284 hasConcept C104317684 @default.
• W2952429284 hasConcept C127413603 @default.
• W2952429284 hasConcept C134066672 @default.
• W2952429284 hasConcept C144024400 @default.
• W2952429284 hasConcept C149923435 @default.
• W2952429284 hasConcept C158379750 @default.
• W2952429284 hasConcept C188198153 @default.
• W2952429284 hasConcept C18903297 @default.
• W2952429284 hasConcept C2778060650 @default.
• W2952429284 hasConcept C2908647359 @default.
• W2952429284 hasConcept C38652104 @default.
• W2952429284 hasConcept C41008148 @default.
• W2952429284 hasConcept C54355233 @default.
• W2952429284 hasConcept C78458016 @default.
• W2952429284 hasConcept C78519656 @default.
• W2952429284 hasConcept C84597430 @default.
• W2952429284 hasConcept C86803240 @default.
• W2952429284 hasConcept C98108389 @default.
• W2952429284 hasConceptScore W2952429284C104317684 @default.
• W2952429284 hasConceptScore W2952429284C127413603 @default.
• W2952429284 hasConceptScore W2952429284C134066672 @default.
• W2952429284 hasConceptScore W2952429284C144024400 @default.
• W2952429284 hasConceptScore W2952429284C149923435 @default.
• W2952429284 hasConceptScore W2952429284C158379750 @default.
• W2952429284 hasConceptScore W2952429284C188198153 @default.
• W2952429284 hasConceptScore W2952429284C18903297 @default.
• W2952429284 hasConceptScore W2952429284C2778060650 @default.
• W2952429284 hasConceptScore W2952429284C2908647359 @default.
• W2952429284 hasConceptScore W2952429284C38652104 @default.
• W2952429284 hasConceptScore W2952429284C41008148 @default.
• W2952429284 hasConceptScore W2952429284C54355233 @default.
• W2952429284 hasConceptScore W2952429284C78458016 @default.

• next