FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952436701> ?p ?o ?g. }

• W2952436701 endingPage "2544" @default.
• W2952436701 startingPage "2533" @default.
• W2952436701 abstract "Abstract Expression quantitative trait locus (eQTL) detection has emerged as an important tool for unraveling of the relationship between genetic risk factors and disease or clinical phenotypes. Most studies use single marker linear regression to discover primary signals, followed by sequential conditional modeling to detect secondary genetic variants affecting gene expression. However, this approach assumes that functional variants are sparsely distributed and that close linkage between them has little impact on estimation of their precise location and the magnitude of effects. We describe a series of simulation studies designed to evaluate the impact of linkage disequilibrium (LD) on the fine mapping of causal variants with typical eQTL effect sizes. In the presence of multisite regulation, even though between 80 and 90% of modeled eSNPs associate with normally distributed traits, up to 10% of all secondary signals could be statistical artifacts, and at least 5% but up to one-quarter of credible intervals of SNPs within r2 &gt; 0.8 of the peak may not even include a causal site. The Bayesian methods eCAVIAR and DAP (Deterministic Approximation of Posteriors) provide only modest improvement in resolution. Given the strong empirical evidence that gene expression is commonly regulated by more than one variant, we conclude that the fine mapping of causal variants needs to be adjusted for multisite influences, as conditional estimates can be highly biased by interference among linked sites, but ultimately experimental verification of individual effects is needed. Presumably similar conclusions apply not just to eQTL mapping, but to multisite influences on fine mapping of most types of quantitative trait." @default.
• W2952436701 created "2019-06-27" @default.
• W2952436701 creator A5002628620 @default.
• W2952436701 creator A5007189110 @default.
• W2952436701 creator A5020502354 @default.
• W2952436701 creator A5024982512 @default.
• W2952436701 creator A5029677222 @default.
• W2952436701 creator A5030412845 @default.
• W2952436701 creator A5036425353 @default.
• W2952436701 creator A5043163204 @default.
• W2952436701 creator A5045721274 @default.
• W2952436701 creator A5061640269 @default.
• W2952436701 creator A5063458641 @default.
• W2952436701 creator A5080937461 @default.
• W2952436701 creator A5081361612 @default.
• W2952436701 creator A5087161283 @default.
• W2952436701 date "2017-08-01" @default.
• W2952436701 modified "2023-10-16" @default.
• W2952436701 title "Constraints on eQTL Fine Mapping in the Presence of Multisite Local Regulation of Gene Expression" @default.
• W2952436701 cites W1514567872 @default.
• W2952436701 cites W1529287480 @default.
• W2952436701 cites W1844405070 @default.
• W2952436701 cites W1862369546 @default.
• W2952436701 cites W1981041672 @default.
• W2952436701 cites W1993616000 @default.
• W2952436701 cites W1999999098 @default.
• W2952436701 cites W2012949385 @default.
• W2952436701 cites W2015751862 @default.
• W2952436701 cites W2019983262 @default.
• W2952436701 cites W2025943989 @default.
• W2952436701 cites W2029892338 @default.
• W2952436701 cites W2039627167 @default.
• W2952436701 cites W2052628795 @default.
• W2952436701 cites W2054344444 @default.
• W2952436701 cites W2056198580 @default.
• W2952436701 cites W2057239687 @default.
• W2952436701 cites W2059867286 @default.
• W2952436701 cites W2073836327 @default.
• W2952436701 cites W2076154138 @default.
• W2952436701 cites W2078059415 @default.
• W2952436701 cites W2085126855 @default.
• W2952436701 cites W2091434498 @default.
• W2952436701 cites W2095486248 @default.
• W2952436701 cites W2099480878 @default.
• W2952436701 cites W2101505979 @default.
• W2952436701 cites W2102219421 @default.
• W2952436701 cites W2103869992 @default.
• W2952436701 cites W2111307685 @default.
• W2952436701 cites W2133009026 @default.
• W2952436701 cites W2135199713 @default.
• W2952436701 cites W2139852278 @default.
• W2952436701 cites W2152325859 @default.
• W2952436701 cites W2152435464 @default.
• W2952436701 cites W2152885121 @default.
• W2952436701 cites W2159417227 @default.
• W2952436701 cites W2160995259 @default.
• W2952436701 cites W2164531600 @default.
• W2952436701 cites W2177538943 @default.
• W2952436701 cites W2185560378 @default.
• W2952436701 cites W2188707104 @default.
• W2952436701 cites W2259938310 @default.
• W2952436701 cites W2269787281 @default.
• W2952436701 cites W2297334215 @default.
• W2952436701 cites W2400221198 @default.
• W2952436701 cites W2412481123 @default.
• W2952436701 cites W2427717657 @default.
• W2952436701 cites W2555614465 @default.
• W2952436701 cites W2567827323 @default.
• W2952436701 cites W2590321928 @default.
• W2952436701 cites W2595351638 @default.
• W2952436701 cites W2724938313 @default.
• W2952436701 cites W2962931338 @default.
• W2952436701 doi "https://doi.org/10.1534/g3.117.043752" @default.
• W2952436701 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5555460" @default.
• W2952436701 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28600440" @default.
• W2952436701 hasPublicationYear "2017" @default.
• W2952436701 type Work @default.
• W2952436701 sameAs 2952436701 @default.
• W2952436701 citedByCount "23" @default.
• W2952436701 countsByYear W29524367012018 @default.
• W2952436701 countsByYear W29524367012019 @default.
• W2952436701 countsByYear W29524367012020 @default.
• W2952436701 countsByYear W29524367012021 @default.
• W2952436701 countsByYear W29524367012022 @default.
• W2952436701 countsByYear W29524367012023 @default.
• W2952436701 crossrefType "journal-article" @default.
• W2952436701 hasAuthorship W2952436701A5002628620 @default.
• W2952436701 hasAuthorship W2952436701A5007189110 @default.
• W2952436701 hasAuthorship W2952436701A5020502354 @default.
• W2952436701 hasAuthorship W2952436701A5024982512 @default.
• W2952436701 hasAuthorship W2952436701A5029677222 @default.
• W2952436701 hasAuthorship W2952436701A5030412845 @default.
• W2952436701 hasAuthorship W2952436701A5036425353 @default.
• W2952436701 hasAuthorship W2952436701A5043163204 @default.
• W2952436701 hasAuthorship W2952436701A5045721274 @default.
• W2952436701 hasAuthorship W2952436701A5061640269 @default.
• W2952436701 hasAuthorship W2952436701A5063458641 @default.
• W2952436701 hasAuthorship W2952436701A5080937461 @default.

• next