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- W2952441027 abstract "Two syntheses of the novel CNS agent, 2-fluoro-4-(trans)-(4-(3‘H-spiro[cyclohex-1,1‘-isobenzofuran]-4-yl)-piperazin-1-yl)-benzonitrile, 1, are presented. The first relied on a reductive alkylation with low regioselectivity (1:1) but was sufficient for the preparation of kilogram quantities. The second used a selective ketone reduction of 3‘H-spiro[cyclohexane-1,1‘-isobenzofuran]-4-one, 8, with sodium borohydride to provide the cis-alcohol, 3‘H-spiro[cyclohexane-1,1‘-isobenzofuran]-(cis)-4-ol, 11. A simple process for the conversion of 11 to 1 is described. Regioselective reactions with 2,4-difluorobenzonitrile under mild conditions are described." @default.
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- W2952441027 date "1999-10-27" @default.
- W2952441027 modified "2023-09-26" @default.
- W2952441027 title "Synthesis of a Spiro[cyclohex-1,1‘-isobenzofuranyl] Dopamine Receptor Antagonist" @default.
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- W2952441027 doi "https://doi.org/10.1021/op990191u" @default.
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