Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952442045> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2952442045 abstract "SETD8/SET8/Pr-SET7/KMT5A is the only known lysine methyltransferase that monomethylates lysine 20 of histone H4 (H4K20) in vivo. The methyltransferase activity of SETD8 has been implicated in many essential cellular processes, including DNA replication, DNA damage response, transcription modulation, and cell cycle regulation. In addition to H4K20, SETD8 monomethylates non-histone substrates including proliferating cell nuclear antigen and p53. During the past decade, different structural classes of inhibitors targeting various lysine methyltransferases have been designed and developed. However, the development of SETD8 inhibitors is still in its infancy. This review covers the progress made to date in inhibiting the activity of SETD8 by small molecules, with an emphasis on their discovery, selectivity over other methyltransferases, and cellular activity." @default.
- W2952442045 created "2019-06-27" @default.
- W2952442045 creator A5012577015 @default.
- W2952442045 creator A5012839091 @default.
- W2952442045 creator A5017825556 @default.
- W2952442045 creator A5041402506 @default.
- W2952442045 creator A5059757863 @default.
- W2952442045 creator A5062146508 @default.
- W2952442045 creator A5062240357 @default.
- W2952442045 date "2016-09-01" @default.
- W2952442045 modified "2023-09-22" @default.
- W2952442045 title "ChemInform Abstract: Progress in the Development of Lysine Methyltransferase SETD8 Inhibitors" @default.
- W2952442045 cites W2462711050 @default.
- W2952442045 doi "https://doi.org/10.1002/chin.201642266" @default.
- W2952442045 hasPublicationYear "2016" @default.
- W2952442045 type Work @default.
- W2952442045 sameAs 2952442045 @default.
- W2952442045 citedByCount "0" @default.
- W2952442045 crossrefType "journal-article" @default.
- W2952442045 hasAuthorship W2952442045A5012577015 @default.
- W2952442045 hasAuthorship W2952442045A5012839091 @default.
- W2952442045 hasAuthorship W2952442045A5017825556 @default.
- W2952442045 hasAuthorship W2952442045A5041402506 @default.
- W2952442045 hasAuthorship W2952442045A5059757863 @default.
- W2952442045 hasAuthorship W2952442045A5062146508 @default.
- W2952442045 hasAuthorship W2952442045A5062240357 @default.
- W2952442045 hasConcept C138885662 @default.
- W2952442045 hasConcept C150425827 @default.
- W2952442045 hasConcept C179926584 @default.
- W2952442045 hasConcept C185592680 @default.
- W2952442045 hasConcept C2776016237 @default.
- W2952442045 hasConcept C2779085176 @default.
- W2952442045 hasConcept C33288867 @default.
- W2952442045 hasConcept C34688535 @default.
- W2952442045 hasConcept C41895202 @default.
- W2952442045 hasConcept C515207424 @default.
- W2952442045 hasConcept C552990157 @default.
- W2952442045 hasConcept C55493867 @default.
- W2952442045 hasConcept C62112901 @default.
- W2952442045 hasConcept C64927066 @default.
- W2952442045 hasConcept C86803240 @default.
- W2952442045 hasConcept C91965660 @default.
- W2952442045 hasConcept C95444343 @default.
- W2952442045 hasConceptScore W2952442045C138885662 @default.
- W2952442045 hasConceptScore W2952442045C150425827 @default.
- W2952442045 hasConceptScore W2952442045C179926584 @default.
- W2952442045 hasConceptScore W2952442045C185592680 @default.
- W2952442045 hasConceptScore W2952442045C2776016237 @default.
- W2952442045 hasConceptScore W2952442045C2779085176 @default.
- W2952442045 hasConceptScore W2952442045C33288867 @default.
- W2952442045 hasConceptScore W2952442045C34688535 @default.
- W2952442045 hasConceptScore W2952442045C41895202 @default.
- W2952442045 hasConceptScore W2952442045C515207424 @default.
- W2952442045 hasConceptScore W2952442045C552990157 @default.
- W2952442045 hasConceptScore W2952442045C55493867 @default.
- W2952442045 hasConceptScore W2952442045C62112901 @default.
- W2952442045 hasConceptScore W2952442045C64927066 @default.
- W2952442045 hasConceptScore W2952442045C86803240 @default.
- W2952442045 hasConceptScore W2952442045C91965660 @default.
- W2952442045 hasConceptScore W2952442045C95444343 @default.
- W2952442045 hasLocation W29524420451 @default.
- W2952442045 hasOpenAccess W2952442045 @default.
- W2952442045 hasPrimaryLocation W29524420451 @default.
- W2952442045 hasRelatedWork W1955947014 @default.
- W2952442045 hasRelatedWork W1965243701 @default.
- W2952442045 hasRelatedWork W1984164650 @default.
- W2952442045 hasRelatedWork W2013168688 @default.
- W2952442045 hasRelatedWork W2137445724 @default.
- W2952442045 hasRelatedWork W2234713656 @default.
- W2952442045 hasRelatedWork W2293119823 @default.
- W2952442045 hasRelatedWork W2317472577 @default.
- W2952442045 hasRelatedWork W2337102023 @default.
- W2952442045 hasRelatedWork W2462711050 @default.
- W2952442045 hasRelatedWork W2503056487 @default.
- W2952442045 hasRelatedWork W2753766712 @default.
- W2952442045 hasRelatedWork W2780197283 @default.
- W2952442045 hasRelatedWork W2792428607 @default.
- W2952442045 hasRelatedWork W2909193231 @default.
- W2952442045 hasRelatedWork W2929742968 @default.
- W2952442045 hasRelatedWork W2947141972 @default.
- W2952442045 hasRelatedWork W2990990711 @default.
- W2952442045 hasRelatedWork W3203845059 @default.
- W2952442045 hasRelatedWork W3207435147 @default.
- W2952442045 isParatext "false" @default.
- W2952442045 isRetracted "false" @default.
- W2952442045 magId "2952442045" @default.
- W2952442045 workType "article" @default.