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- W2952464260 abstract "Osteosarcoma (OS) is an aggressive malignancy affecting mostly children and adolescents. MicroRNAs (miRNAs) play important roles in OS development and progression. Here we found that miR‐16‐1‐3p and miR‐16‐2‐3p “passenger” strands, as well as the “lead” miR‐16‐5p strand, are frequently downregulated and possess strong tumor suppressive functions in human OS. Furthermore, we report different although strongly overlapping functions for miR‐16‐1‐3p and miR‐16‐2‐3p in OS cells. Ectopic expression of these miRNAs affected primary tumor growth, metastasis seeding and chemoresistance and invasiveness of human OS cells. Loss‐of‐function experiments verified tumor suppressive functions of these miRNAs at endogenous levels of expression. Using RNA immunoprecipitation (RIP) assays, we identify direct targets of miR‐16‐1‐3p and miR‐16‐2‐3p in OS cells. Moreover, validation experiments identified FGFR2 as a direct target for miR‐16‐1‐3p and miR‐16‐2‐3p. Overall, our findings underscore the importance of passenger strand miRNAs, at least some, in osteosarcomagenesis." @default.
- W2952464260 created "2019-06-27" @default.
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- W2952464260 date "2019-05-09" @default.
- W2952464260 modified "2023-10-18" @default.
- W2952464260 title "MiR‐16‐1‐3p and miR‐16‐2‐3p possess strong tumor suppressive and antimetastatic properties in osteosarcoma" @default.
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- W2952464260 doi "https://doi.org/10.1002/ijc.32368" @default.
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