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• W2952472386 endingPage "548" @default.
• W2952472386 startingPage "535" @default.
• W2952472386 abstract "Genetic porphyrias comprise eight diseases caused by defects in the heme biosynthetic pathway that lead to accumulation of heme precursors. Consequences of porphyria include photosensitivity, liver damage and increased risk of hepatocellular carcinoma, and neurovisceral involvement, including seizures. Fluorescent porphyrins that include protoporphyrin-IX, uroporphyrin and coproporphyrin, are photo-reactive; they absorb light energy and are excited to high-energy singlet and triplet states. Decay of the porphyrin excited to ground state releases energy and generates singlet oxygen. Porphyrin-induced oxidative stress is thought to be the major mechanism of porphyrin-mediated tissue damage. Although this explains the acute photosensitivity in most porphyrias, light-induced porphyrin-mediated oxidative stress does not account for the effect of porphyrins on internal organs. Recent findings demonstrate the unique role of fluorescent porphyrins in causing subcellular compartment-selective protein aggregation. Porphyrin-mediated protein aggregation associates with nuclear deformation, cytoplasmic vacuole formation and endoplasmic reticulum dilation. Porphyrin-triggered proteotoxicity is compounded by inhibition of the proteasome due to aggregation of some of its subunits. The ensuing disruption in proteostasis also manifests in cell cycle arrest coupled with aggregation of cell proliferation-related proteins, including PCNA, cdk4 and cyclin B1. Porphyrins bind to native proteins and, in presence of light and oxygen, oxidize several amino acids, particularly methionine. Noncovalent interaction of oxidized proteins with porphyrins leads to formation of protein aggregates. In internal organs, particularly the liver, light-independent porphyrin-mediated protein aggregation occurs after secondary triggers of oxidative stress. Thus, porphyrin-induced protein aggregation provides a novel mechanism for external and internal tissue damage in porphyrias that involve fluorescent porphyrin accumulation." @default.
• W2952472386 created "2019-06-27" @default.
• W2952472386 creator A5007337339 @default.
• W2952472386 creator A5017892286 @default.
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• W2952472386 creator A5061094961 @default.
• W2952472386 creator A5066255279 @default.
• W2952472386 date "2019-01-01" @default.
• W2952472386 modified "2023-10-17" @default.
• W2952472386 title "Porphyrin-Induced Protein Oxidation and Aggregation as a Mechanism of Porphyria-Associated Cell Injury" @default.
• W2952472386 cites W1522964919 @default.
• W2952472386 cites W1543863358 @default.
• W2952472386 cites W1560354598 @default.
• W2952472386 cites W1581852181 @default.
• W2952472386 cites W1610046461 @default.
• W2952472386 cites W1709418723 @default.
• W2952472386 cites W1891095862 @default.
• W2952472386 cites W1901040683 @default.
• W2952472386 cites W1963890030 @default.
• W2952472386 cites W1964893456 @default.
• W2952472386 cites W1965378211 @default.
• W2952472386 cites W1965956540 @default.
• W2952472386 cites W1966265565 @default.
• W2952472386 cites W1967659791 @default.
• W2952472386 cites W1968577485 @default.
• W2952472386 cites W1971541698 @default.
• W2952472386 cites W1972434802 @default.
• W2952472386 cites W1974125090 @default.
• W2952472386 cites W1977605312 @default.
• W2952472386 cites W1977748061 @default.
• W2952472386 cites W1981600991 @default.
• W2952472386 cites W1985614068 @default.
• W2952472386 cites W1990348497 @default.
• W2952472386 cites W1990549533 @default.
• W2952472386 cites W1991581322 @default.
• W2952472386 cites W1994999960 @default.
• W2952472386 cites W1995980300 @default.
• W2952472386 cites W1996991268 @default.
• W2952472386 cites W1997871585 @default.
• W2952472386 cites W1999921360 @default.
• W2952472386 cites W2000934453 @default.
• W2952472386 cites W2002937223 @default.
• W2952472386 cites W2004118825 @default.
• W2952472386 cites W2006754144 @default.
• W2952472386 cites W2008678591 @default.
• W2952472386 cites W2010594881 @default.
• W2952472386 cites W2011048815 @default.
• W2952472386 cites W2013438056 @default.
• W2952472386 cites W2014593263 @default.
• W2952472386 cites W2015886351 @default.
• W2952472386 cites W2018735093 @default.
• W2952472386 cites W2019501296 @default.
• W2952472386 cites W2022334625 @default.
• W2952472386 cites W2022865646 @default.
• W2952472386 cites W2025678527 @default.
• W2952472386 cites W2026889493 @default.
• W2952472386 cites W2029958015 @default.
• W2952472386 cites W2030028187 @default.
• W2952472386 cites W2030705564 @default.
• W2952472386 cites W2034973225 @default.
• W2952472386 cites W2036268002 @default.
• W2952472386 cites W2037539395 @default.
• W2952472386 cites W2041477822 @default.
• W2952472386 cites W2041790279 @default.
• W2952472386 cites W2044887439 @default.
• W2952472386 cites W2046971384 @default.
• W2952472386 cites W2047913421 @default.
• W2952472386 cites W2048541682 @default.
• W2952472386 cites W2048640056 @default.
• W2952472386 cites W2048759704 @default.
• W2952472386 cites W2051486459 @default.
• W2952472386 cites W2052425126 @default.
• W2952472386 cites W2053359068 @default.
• W2952472386 cites W2053649957 @default.
• W2952472386 cites W2062273647 @default.
• W2952472386 cites W2063343728 @default.
• W2952472386 cites W2065483452 @default.
• W2952472386 cites W2065685812 @default.
• W2952472386 cites W2065850291 @default.
• W2952472386 cites W2066182761 @default.
• W2952472386 cites W2067442819 @default.
• W2952472386 cites W2067595418 @default.
• W2952472386 cites W2068183958 @default.
• W2952472386 cites W2068689727 @default.
• W2952472386 cites W2069360361 @default.
• W2952472386 cites W2069536180 @default.
• W2952472386 cites W2069658951 @default.
• W2952472386 cites W2070367241 @default.
• W2952472386 cites W2075572654 @default.
• W2952472386 cites W2076565678 @default.
• W2952472386 cites W2087445490 @default.
• W2952472386 cites W2088576571 @default.
• W2952472386 cites W2093804948 @default.
• W2952472386 cites W2094745004 @default.
• W2952472386 cites W2103136993 @default.
• W2952472386 cites W2104185157 @default.
• W2952472386 cites W2106348878 @default.

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