Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952473375> ?p ?o ?g. }
- W2952473375 abstract "In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer’s disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we developed an internet-based paired-associates learning (PAL) task and tested 59,571 participants between the ages of 18–85. FH was associated with lower PAL performance in both sexes under 65 years old. Modifiers of this effect of FH on PAL performance included age, sex, education, and diabetes. The Apolipoprotein E ε4 allele was also associated with lower PAL scores in FH positive individuals. Here we show, FH is associated with reduced PAL performance four decades before the typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect were identified." @default.
- W2952473375 created "2019-06-27" @default.
- W2952473375 creator A5001700176 @default.
- W2952473375 creator A5012986765 @default.
- W2952473375 creator A5015978195 @default.
- W2952473375 creator A5021195592 @default.
- W2952473375 creator A5028103234 @default.
- W2952473375 creator A5029381078 @default.
- W2952473375 creator A5035160894 @default.
- W2952473375 creator A5036840732 @default.
- W2952473375 creator A5037628555 @default.
- W2952473375 creator A5042422785 @default.
- W2952473375 creator A5059222630 @default.
- W2952473375 creator A5072995604 @default.
- W2952473375 creator A5075079684 @default.
- W2952473375 creator A5084903781 @default.
- W2952473375 creator A5091890407 @default.
- W2952473375 date "2019-06-18" @default.
- W2952473375 modified "2023-09-27" @default.
- W2952473375 title "Family history of Alzheimer’s disease alters cognition and is modified by medical and genetic factors" @default.
- W2952473375 cites W1644155731 @default.
- W2952473375 cites W1860699892 @default.
- W2952473375 cites W1871783318 @default.
- W2952473375 cites W1964256401 @default.
- W2952473375 cites W1964464904 @default.
- W2952473375 cites W1965337231 @default.
- W2952473375 cites W1970381807 @default.
- W2952473375 cites W1970810798 @default.
- W2952473375 cites W1981972461 @default.
- W2952473375 cites W1993023011 @default.
- W2952473375 cites W1996806161 @default.
- W2952473375 cites W2010192073 @default.
- W2952473375 cites W2010521301 @default.
- W2952473375 cites W2029509511 @default.
- W2952473375 cites W2031779126 @default.
- W2952473375 cites W2046364590 @default.
- W2952473375 cites W2049951659 @default.
- W2952473375 cites W2063249530 @default.
- W2952473375 cites W2069272002 @default.
- W2952473375 cites W2071068165 @default.
- W2952473375 cites W2091585384 @default.
- W2952473375 cites W2117013044 @default.
- W2952473375 cites W2121091792 @default.
- W2952473375 cites W2135255861 @default.
- W2952473375 cites W2136520115 @default.
- W2952473375 cites W2139577967 @default.
- W2952473375 cites W2152532350 @default.
- W2952473375 cites W2152849583 @default.
- W2952473375 cites W2163723040 @default.
- W2952473375 cites W2264369089 @default.
- W2952473375 cites W2468889233 @default.
- W2952473375 cites W254156291 @default.
- W2952473375 cites W2586512779 @default.
- W2952473375 cites W2626589460 @default.
- W2952473375 cites W2766186892 @default.
- W2952473375 cites W2792200600 @default.
- W2952473375 cites W2792748998 @default.
- W2952473375 cites W2888707262 @default.
- W2952473375 cites W2921819616 @default.
- W2952473375 doi "https://doi.org/10.7554/elife.46179" @default.
- W2952473375 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6615857" @default.
- W2952473375 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31210642" @default.
- W2952473375 hasPublicationYear "2019" @default.
- W2952473375 type Work @default.
- W2952473375 sameAs 2952473375 @default.
- W2952473375 citedByCount "23" @default.
- W2952473375 countsByYear W29524733752020 @default.
- W2952473375 countsByYear W29524733752021 @default.
- W2952473375 countsByYear W29524733752022 @default.
- W2952473375 countsByYear W29524733752023 @default.
- W2952473375 crossrefType "journal-article" @default.
- W2952473375 hasAuthorship W2952473375A5001700176 @default.
- W2952473375 hasAuthorship W2952473375A5012986765 @default.
- W2952473375 hasAuthorship W2952473375A5015978195 @default.
- W2952473375 hasAuthorship W2952473375A5021195592 @default.
- W2952473375 hasAuthorship W2952473375A5028103234 @default.
- W2952473375 hasAuthorship W2952473375A5029381078 @default.
- W2952473375 hasAuthorship W2952473375A5035160894 @default.
- W2952473375 hasAuthorship W2952473375A5036840732 @default.
- W2952473375 hasAuthorship W2952473375A5037628555 @default.
- W2952473375 hasAuthorship W2952473375A5042422785 @default.
- W2952473375 hasAuthorship W2952473375A5059222630 @default.
- W2952473375 hasAuthorship W2952473375A5072995604 @default.
- W2952473375 hasAuthorship W2952473375A5075079684 @default.
- W2952473375 hasAuthorship W2952473375A5084903781 @default.
- W2952473375 hasAuthorship W2952473375A5091890407 @default.
- W2952473375 hasBestOaLocation W29524733751 @default.
- W2952473375 hasConcept C104317684 @default.
- W2952473375 hasConcept C126322002 @default.
- W2952473375 hasConcept C138496976 @default.
- W2952473375 hasConcept C15744967 @default.
- W2952473375 hasConcept C169760540 @default.
- W2952473375 hasConcept C169900460 @default.
- W2952473375 hasConcept C180754005 @default.
- W2952473375 hasConcept C197754878 @default.
- W2952473375 hasConcept C2779134260 @default.
- W2952473375 hasConcept C2779483572 @default.
- W2952473375 hasConcept C2781179581 @default.
- W2952473375 hasConcept C502032728 @default.
- W2952473375 hasConcept C54355233 @default.