FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952474268> ?p ?o ?g. }

• W2952474268 abstract "The analysis of whole genome has revealed specific geographical distribution of Mycobacterium tuberculosis (Mtb) strains across the globe suggestive of unique host dependent adaptive mechanisms in Mtb evolved out of selective pressures. We provide an important correlation of a genome-based mutation to a molecular phenotype across two predominant clinical Mtb lineages of the Indian subcontinent. We have identified a distinct lineage specific mutation-G247C, translating into an alanine to proline conversion in the papA2 gene of Indo oceanic lineage 1 [L1] Mtb strains; restoration of cell wall sulfolipids by simple genetic complementation of papA2 from lineage 3 [L3] or from H37Rv (Lineage 4- L4) attributed the loss of this glycolipid to this specific mutation in Indo oceanic L1 Mtb. Investigation into the structure of Mtb PapA2 revealed a distinct non-ribosomal peptide synthetase (NRPS) C domain conformation with an unconventional presence of Zinc binding motif. Surprisingly, the A83P mutation did not map to either the catalytic centre in the N-terminal subdomain or any of the substrate binding region of the protein. On the contrary, the inherent ability of mutant PapA2 to form insoluble aggregates and molecular simulations with the Wt/ mut PapA2 purports an important role for the surface associated 83rd residue in protein conformation. The present study demonstrates the importance of a critical structural residue in the papA2 protein of Mtb and helps establish a link between observed genomic alteration and its molecular consequence in the successful human pathogen Mtb." @default.
• W2952474268 created "2019-06-27" @default.
• W2952474268 creator A5002480644 @default.
• W2952474268 creator A5003745249 @default.
• W2952474268 creator A5016293777 @default.
• W2952474268 creator A5018966703 @default.
• W2952474268 creator A5043928368 @default.
• W2952474268 creator A5050126936 @default.
• W2952474268 creator A5060090073 @default.
• W2952474268 creator A5065207562 @default.
• W2952474268 creator A5074694381 @default.
• W2952474268 creator A5085420858 @default.
• W2952474268 date "2018-12-05" @default.
• W2952474268 modified "2023-09-28" @default.
• W2952474268 title "A novel mutation alters the stability of PapA2 resulting in the complete abrogation of sulfolipids in clinical mycobacterial strains" @default.
• W2952474268 cites W1428838771 @default.
• W2952474268 cites W1539796472 @default.
• W2952474268 cites W1923328202 @default.
• W2952474268 cites W1970470428 @default.
• W2952474268 cites W197096261 @default.
• W2952474268 cites W1971511191 @default.
• W2952474268 cites W1973428805 @default.
• W2952474268 cites W1976870904 @default.
• W2952474268 cites W1977138279 @default.
• W2952474268 cites W1989118552 @default.
• W2952474268 cites W1993977508 @default.
• W2952474268 cites W2007343995 @default.
• W2952474268 cites W2009191897 @default.
• W2952474268 cites W2013972132 @default.
• W2952474268 cites W2018849951 @default.
• W2952474268 cites W2020631195 @default.
• W2952474268 cites W2022801981 @default.
• W2952474268 cites W2041999173 @default.
• W2952474268 cites W2046053895 @default.
• W2952474268 cites W2059504647 @default.
• W2952474268 cites W2060872411 @default.
• W2952474268 cites W2066410876 @default.
• W2952474268 cites W2067576392 @default.
• W2952474268 cites W2070752321 @default.
• W2952474268 cites W2072325916 @default.
• W2952474268 cites W2072680575 @default.
• W2952474268 cites W2084746693 @default.
• W2952474268 cites W2094787193 @default.
• W2952474268 cites W2096992728 @default.
• W2952474268 cites W2103714813 @default.
• W2952474268 cites W2104335702 @default.
• W2952474268 cites W2105341822 @default.
• W2952474268 cites W2108921801 @default.
• W2952474268 cites W2110485939 @default.
• W2952474268 cites W2112295785 @default.
• W2952474268 cites W2114685191 @default.
• W2952474268 cites W2123440974 @default.
• W2952474268 cites W2124026197 @default.
• W2952474268 cites W2137825366 @default.
• W2952474268 cites W2138384477 @default.
• W2952474268 cites W2154197653 @default.
• W2952474268 cites W2154292013 @default.
• W2952474268 cites W2157179706 @default.
• W2952474268 cites W2162264448 @default.
• W2952474268 cites W2163341755 @default.
• W2952474268 cites W2168568296 @default.
• W2952474268 cites W2180229411 @default.
• W2952474268 cites W2193412202 @default.
• W2952474268 cites W2318389193 @default.
• W2952474268 cites W2592510217 @default.
• W2952474268 cites W2606129977 @default.
• W2952474268 cites W2608596891 @default.
• W2952474268 cites W48248738 @default.
• W2952474268 doi "https://doi.org/10.1101/487124" @default.
• W2952474268 hasPublicationYear "2018" @default.
• W2952474268 type Work @default.
• W2952474268 sameAs 2952474268 @default.
• W2952474268 citedByCount "0" @default.
• W2952474268 crossrefType "posted-content" @default.
• W2952474268 hasAuthorship W2952474268A5002480644 @default.
• W2952474268 hasAuthorship W2952474268A5003745249 @default.
• W2952474268 hasAuthorship W2952474268A5016293777 @default.
• W2952474268 hasAuthorship W2952474268A5018966703 @default.
• W2952474268 hasAuthorship W2952474268A5043928368 @default.
• W2952474268 hasAuthorship W2952474268A5050126936 @default.
• W2952474268 hasAuthorship W2952474268A5060090073 @default.
• W2952474268 hasAuthorship W2952474268A5065207562 @default.
• W2952474268 hasAuthorship W2952474268A5074694381 @default.
• W2952474268 hasAuthorship W2952474268A5085420858 @default.
• W2952474268 hasBestOaLocation W29524742681 @default.
• W2952474268 hasConcept C104317684 @default.
• W2952474268 hasConcept C143065580 @default.
• W2952474268 hasConcept C16318435 @default.
• W2952474268 hasConcept C188082640 @default.
• W2952474268 hasConcept C2776817793 @default.
• W2952474268 hasConcept C2780227090 @default.
• W2952474268 hasConcept C501734568 @default.
• W2952474268 hasConcept C54355233 @default.
• W2952474268 hasConcept C86803240 @default.
• W2952474268 hasConceptScore W2952474268C104317684 @default.
• W2952474268 hasConceptScore W2952474268C143065580 @default.
• W2952474268 hasConceptScore W2952474268C16318435 @default.
• W2952474268 hasConceptScore W2952474268C188082640 @default.
• W2952474268 hasConceptScore W2952474268C2776817793 @default.
• W2952474268 hasConceptScore W2952474268C2780227090 @default.

• next