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• W2952487777 abstract "Abstract Mouse Apolipoprotein L9 is a 34-kDa phosphatidylethanolamine (PE)-binding protein. The gene is present only in mouse and rat genomes; hence it is taxonomically restricted. To understand why, it is essential to uncover details about its functions in cellular processes. Here we show that ApoL9 interacts with the proteins of the LC3 and GABARAP subfamilies, which are key players in macroautophagy. In amino-acid starved cells it preferentially interacts with lipidated LC3B, likely by binding to its PE moiety. On treatment with autophagy inhibitors bafilomycin A1 and chloroquine, ApoL9 is found near swollen mitochondria and on lysosomes/LAMP1-positive compartments. However, ApoL9 itself does not seem to be degraded as a result of autophagy, suggesting that it is not an autophagy cargo receptor. Deletions in a putative transmembrane region between amino acids 110 and 145 abolish PE-binding. In addition, ApoL9 can redistribute to stress granules, can homooligomerize, and is a microtubule-associated protein. In short, its distribution in the cell is quite widespread, suggesting that it could have functions at the intersection of membrane binding and reorganization, autophagy, cellular stress and intracellular lipid transport. Summary statement This article is about how Apolipoprotein L9, a lipid-binding protein, has versatile properties and influences a variety of processes taking place inside an animal cell." @default.
• W2952487777 created "2019-06-27" @default.
• W2952487777 creator A5012114138 @default.
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• W2952487777 date "2019-06-13" @default.
• W2952487777 modified "2023-09-26" @default.
• W2952487777 title "Apolipoprotein L9 interacts with LC3/GABARAP and is a microtubule-associated protein with a widespread subcellular distribution" @default.
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• W2952487777 doi "https://doi.org/10.1101/671065" @default.
• W2952487777 hasPublicationYear "2019" @default.
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