FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952502476> ?p ?o ?g. }

• W2952502476 endingPage "025001" @default.
• W2952502476 startingPage "025001" @default.
• W2952502476 abstract "Epiretinal prostheses are designed to restore vision in people blinded by photoreceptor degenerative diseases, by directly activating retinal ganglion cells (RGCs) using an electrode array implanted on the retina. In present-day clinical devices, current spread from the stimulating electrode to a distant return electrode often results in the activation of many cells, potentially limiting the quality of artificial vision. In the laboratory, epiretinal activation of RGCs with cellular resolution has been demonstrated with small electrodes, but distant returns may still cause undesirable current spread. Here, the ability of local return stimulation to improve the selective activation of RGCs at cellular resolution was evaluated.A custom multi-electrode array (512 electrodes, 10 μm diameter, 60 μm pitch) was used to simultaneously stimulate and record from RGCs in isolated primate retina. Stimulation near the RGC soma with a single electrode and a distant return was compared to stimulation in which the return was provided by six neighboring electrodes.Local return stimulation enhanced the capability to activate cells near the central electrode (<30 μm) while avoiding cells farther away (>30 μm). This resulted in an improved ability to selectively activate ON and OFF cells, including cells encoding immediately adjacent regions in the visual field.These results suggest that a device that restricts the electric field through local returns could optimize activation of neurons at cellular resolution, improving the quality of artificial vision." @default.
• W2952502476 created "2019-06-27" @default.
• W2952502476 creator A5006381126 @default.
• W2952502476 creator A5026936936 @default.
• W2952502476 creator A5050976622 @default.
• W2952502476 creator A5053189200 @default.
• W2952502476 creator A5053196604 @default.
• W2952502476 creator A5060087057 @default.
• W2952502476 creator A5066869784 @default.
• W2952502476 creator A5072904495 @default.
• W2952502476 date "2019-02-06" @default.
• W2952502476 modified "2023-10-15" @default.
• W2952502476 title "Epiretinal stimulation with local returns enhances selectivity at cellular resolution" @default.
• W2952502476 cites W1978023046 @default.
• W2952502476 cites W1990485400 @default.
• W2952502476 cites W1991784092 @default.
• W2952502476 cites W1992034695 @default.
• W2952502476 cites W1995001599 @default.
• W2952502476 cites W2006097069 @default.
• W2952502476 cites W2007409841 @default.
• W2952502476 cites W2010571331 @default.
• W2952502476 cites W2016971620 @default.
• W2952502476 cites W2022121929 @default.
• W2952502476 cites W2043873236 @default.
• W2952502476 cites W2048932029 @default.
• W2952502476 cites W2050303910 @default.
• W2952502476 cites W2051923857 @default.
• W2952502476 cites W2055126043 @default.
• W2952502476 cites W2057540120 @default.
• W2952502476 cites W2075123461 @default.
• W2952502476 cites W2075146636 @default.
• W2952502476 cites W2083443072 @default.
• W2952502476 cites W2091248960 @default.
• W2952502476 cites W2112455917 @default.
• W2952502476 cites W2117018945 @default.
• W2952502476 cites W2119899246 @default.
• W2952502476 cites W2124181495 @default.
• W2952502476 cites W2125277430 @default.
• W2952502476 cites W2130554078 @default.
• W2952502476 cites W21769058 @default.
• W2952502476 cites W2209723663 @default.
• W2952502476 cites W2312817279 @default.
• W2952502476 cites W2338644482 @default.
• W2952502476 cites W2493700155 @default.
• W2952502476 cites W2523634951 @default.
• W2952502476 cites W2549197590 @default.
• W2952502476 cites W2618872524 @default.
• W2952502476 cites W2620368413 @default.
• W2952502476 cites W2949350296 @default.
• W2952502476 cites W4240629939 @default.
• W2952502476 cites W4245474015 @default.
• W2952502476 doi "https://doi.org/10.1088/1741-2552/aaeef1" @default.
• W2952502476 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6416068" @default.
• W2952502476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30523958" @default.
• W2952502476 hasPublicationYear "2019" @default.
• W2952502476 type Work @default.
• W2952502476 sameAs 2952502476 @default.
• W2952502476 citedByCount "32" @default.
• W2952502476 countsByYear W29525024762019 @default.
• W2952502476 countsByYear W29525024762020 @default.
• W2952502476 countsByYear W29525024762021 @default.
• W2952502476 countsByYear W29525024762022 @default.
• W2952502476 countsByYear W29525024762023 @default.
• W2952502476 crossrefType "journal-article" @default.
• W2952502476 hasAuthorship W2952502476A5006381126 @default.
• W2952502476 hasAuthorship W2952502476A5026936936 @default.
• W2952502476 hasAuthorship W2952502476A5050976622 @default.
• W2952502476 hasAuthorship W2952502476A5053189200 @default.
• W2952502476 hasAuthorship W2952502476A5053196604 @default.
• W2952502476 hasAuthorship W2952502476A5060087057 @default.
• W2952502476 hasAuthorship W2952502476A5066869784 @default.
• W2952502476 hasAuthorship W2952502476A5072904495 @default.
• W2952502476 hasBestOaLocation W29525024762 @default.
• W2952502476 hasConcept C12554922 @default.
• W2952502476 hasConcept C136229726 @default.
• W2952502476 hasConcept C147789679 @default.
• W2952502476 hasConcept C169760540 @default.
• W2952502476 hasConcept C17525397 @default.
• W2952502476 hasConcept C185592680 @default.
• W2952502476 hasConcept C192562407 @default.
• W2952502476 hasConcept C24998067 @default.
• W2952502476 hasConcept C2777093970 @default.
• W2952502476 hasConcept C71924100 @default.
• W2952502476 hasConcept C86803240 @default.
• W2952502476 hasConcept C97562148 @default.
• W2952502476 hasConceptScore W2952502476C12554922 @default.
• W2952502476 hasConceptScore W2952502476C136229726 @default.
• W2952502476 hasConceptScore W2952502476C147789679 @default.
• W2952502476 hasConceptScore W2952502476C169760540 @default.
• W2952502476 hasConceptScore W2952502476C17525397 @default.
• W2952502476 hasConceptScore W2952502476C185592680 @default.
• W2952502476 hasConceptScore W2952502476C192562407 @default.
• W2952502476 hasConceptScore W2952502476C24998067 @default.
• W2952502476 hasConceptScore W2952502476C2777093970 @default.
• W2952502476 hasConceptScore W2952502476C71924100 @default.
• W2952502476 hasConceptScore W2952502476C86803240 @default.
• W2952502476 hasConceptScore W2952502476C97562148 @default.
• W2952502476 hasFunder F4320322511 @default.

• next