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• W2952519293 abstract "Caffeic acid (CA) is a phenolic compound synthesized by all plant species and is present in foods such as coffee, wine, tea and popular medicines such as propolis. This phenolic acid and its derivatives have antioxidant, anti-inflammatory and anticarcinogenic activity. In vitro and in vivo studies have demonstrated the anticarcinogenic activity of this compound against an important type of cancer, hepatocarcinoma (HCC), considered to be of high incidence, highly aggressive and causing considerable mortality across the world. The anticancer properties of CA are associated with its antioxidant and pro-oxidant capacity, attributed to its chemical structure that has free phenolic hydroxyls, the number and position of OH in the catechol group and the double bond in the carbonic chain. Pharmacokinetic studies indicate that this compound is hydrolyzed by the microflora of colonies and metabolized mainly in the intestinal mucosa through phase II enzymes, submitted to conjugation and methylation processes, forming sulphated, glucuronic and / or methylated conjugates by the action of sulfotransferases, UDP-glucotransferases, and o-methyltransferases, respectively. The transmembrane flux of CA in intestinal cells occurs through active transport mediated by monocarboxylic acid carriers. CA can act by preventing the production of ROS (reactive oxygen species), inducing DNA oxidation of cancer cells, as well as reducing tumor cell angiogenesis, blocking STATS (transcription factor and signal translation 3) and suppression of MMP2 and MMP-9 (collagen IV metalloproteases). Thus, this review provides an overview of the chemical and pharmacological parameters of CA and its derivatives, demonstrating its mechanism of action and pharmacokinetic aspects, as well as a critical analysis of its action in the fight against hepatocarcinoma." @default.
• W2952519293 created "2019-06-27" @default.
• W2952519293 creator A5010642446 @default.
• W2952519293 creator A5034615093 @default.
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• W2952519293 creator A5081541514 @default.
• W2952519293 creator A5090854484 @default.
• W2952519293 date "2019-06-21" @default.
• W2952519293 modified "2023-10-17" @default.
• W2952519293 title "Chemical and Pharmacological Aspects of Caffeic Acid and Its Activity in Hepatocarcinoma" @default.
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• W2952519293 doi "https://doi.org/10.3389/fonc.2019.00541" @default.
• W2952519293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6598430" @default.
• W2952519293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31293975" @default.
• W2952519293 hasPublicationYear "2019" @default.

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