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- W2952519790 abstract "Loss of dopaminergic neurons in the substantia nigra is one of the pathogenic hallmarks of Parkinson's disease, yet the underlying molecular mechanisms remain enigmatic. While aberrant redox metabolism strongly associated with iron dysregulation and accumulation of dysfunctional mitochondria is considered as one of the major contributors to neurodegeneration and death of dopaminergic cells, the specific anomalies in the molecular machinery and pathways leading to the PD development and progression have not been identified. The high efficiency and relative simplicity of a new genome editing tool, CRISPR/Cas9, make its applications attractive for deciphering molecular changes driving PD-related impairments of redox metabolism and lipid peroxidation in relation to mishandling of iron, aggregation and oligomerization of alpha-synuclein and mitochondrial injury as well as in mechanisms of mitophagy and programs of regulated cell death (apoptosis and ferroptosis). These insights into the mechanisms of PD pathology may be used for the identification of new targets for therapeutic interventions and innovative approaches to genome editing, including CRISPR/Cas9." @default.
- W2952519790 created "2019-06-27" @default.
- W2952519790 creator A5025786667 @default.
- W2952519790 creator A5029785181 @default.
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- W2952519790 creator A5061037167 @default.
- W2952519790 creator A5063937489 @default.
- W2952519790 creator A5086299939 @default.
- W2952519790 date "2019-11-01" @default.
- W2952519790 modified "2023-10-16" @default.
- W2952519790 title "Interrogating Parkinson's disease associated redox targets: Potential application of CRISPR editing" @default.
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