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- W2952536577 abstract "We have developed biocompatible scaffolds that enable cell fate control with visible light. The scaffolds are based on synthetic collagen-like polypeptide, poly(prolyl-hydroxyprolyl-glycyl) {poly(Pro-Hyp-Gly)} which has been used for cosmetics and other healthcare applications. Bioactive peptides were conjugated to the scaffolds via photoactivation reaction utilizing 488 nm visible light. In addition, the use of a photocleavable crosslinker enables dissociation of chemical moieties by 405 nm laser irradiation. The synthesis scheme enables optical control to attach and detach functional peptides in pre-patterned shapes. Using bone forming peptide (BFP), we demonstrate that calcium deposition by rat bone stromal cells can be directed on the scaffold. Using other signaling molecules and three-dimensional scaffolds, controlled differentiation of stem cells can be achieved by spatio-temporally specific irradiation of confocal microscope laser." @default.
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- W2952536577 date "2019-07-02" @default.
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- W2952536577 title "Optical control of cell differentiation on synthetic collagen-like scaffolds" @default.
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- W2952536577 doi "https://doi.org/10.1080/09205063.2019.1622845" @default.
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