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- W2952543611 abstract "The bioprotective nature of disaccharides is hypothesized to derive from the modification of the hydrogen bonding network of water which protects biomolecules through lowered water activity at the protein interface. Using ultrafast fluorescence spectroscopy we measured the relaxation of bulk water dynamics around the induced dipole moment of two fluorescent probes (Lucifer Yellow Ethylenediamine and Tryptophan). Our results indicate a reduction in bulk water reorganization rate of approximately of 30%. We observe this retardation in the low concentration regime measured at 0.1M and 0.25 M, far below the onset of glassy dynamics. This reduction in water activity could be significant in crowded biological systems, contributing to global change in protein energy landscape, resulting in a significant enhancement of protein stability under environmental stress. We observed similar dynamic reduction for two disaccharide osmolytes, sucrose and trehalose, with trehalose being the more effective dynamic reducer." @default.
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- W2952543611 date "2016-07-21" @default.
- W2952543611 modified "2023-09-30" @default.
- W2952543611 title "Retardation of Bulk Water Dynamics by Disaccharide Osmolytes" @default.
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