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- W2952559967 abstract "Diketo acid derivatives are potent and selective HIV-1 integrase inhibitors. To investigate the detailed synthesis of those derivatives, a series of p/m-[p-(un)substituted phenylsulfonamido]phenyl β-diketo acid derivatives have been designed and synthesized. The quinoxalone derivatives as the potential bioisosteres of the biologically labile β-diketoacid pharmacophores have also been synthesized from reactions of the corresponding diketo acids with o-phenylenediamine. The structures of all diketo acid (ester) and quinoxalone derivatives were confirmed by 1H NMR, 13C NMR, IR, HRMS and/or MS (ESI). X-ray crystallographic analysis of 11b demonstrates a similar arrangement of the side chain of quinoxalone derivatives with the parent diketoacids due to the intramolecular hydrogen bond (O···H–N) and the sp2 hybridization configuration of the two nitrogen atoms of the quinoxalone ring." @default.
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- W2952559967 date "2007-08-01" @default.
- W2952559967 modified "2023-09-27" @default.
- W2952559967 title "Design and Synthesis ofp/m-[p-(un)Substituted Phenylsulfonamido]phenylβ-Diketo Acids and Quinoxalone Derivatives" @default.
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- W2952559967 doi "https://doi.org/10.1002/cjoc.200790219" @default.
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