Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952568251> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2952568251 endingPage "361" @default.
- W2952568251 startingPage "353" @default.
- W2952568251 abstract "A series of 5-[4-(arylpiperazin-1-yl)alkylamino]-4-benzyl-3-methyl-1,2-oxaz in-6-ones was synthesized and evaluated for analgesic activity. The structures of these new oxazine derivatives were confirmed by IR, 1H-NMR spectra and by elemental analysis. The three most active compounds, 3c, 3e and 3g possessed significant antinociceptive effects in the phenylbenzoquinone-induced wrigthing test (PBQ-test) in mice, with ED50 values ranging from 19.7 to 68.0 mg/kg i.p. In addition these compounds presented a low toxicity (LD50 > 800 mg/kg i.p.) and did not significantly reduce the spontaneous locomotor activity of mice. They interacted in a synergistic manner with morphine but nevertheless each compound presented its own profile. Thus the analgesic activity of 3c and 3e was naloxone sensitive, suggesting in mu opioidergic mechanism. Otherwise 3c and 3d analgesia was attenuated by oral administration of yohimbine and therefore seemed to be mediated via noradrenergic pathway. Finally, 5-hydroxytryptophan associated to carbidopa only potentiated 3e analgesia, demonstrating an involvement of a serotoninergic mechanism." @default.
- W2952568251 created "2019-06-27" @default.
- W2952568251 creator A5013074392 @default.
- W2952568251 creator A5017594177 @default.
- W2952568251 creator A5019481950 @default.
- W2952568251 creator A5045046138 @default.
- W2952568251 creator A5057363669 @default.
- W2952568251 creator A5080352069 @default.
- W2952568251 date "2011-12-27" @default.
- W2952568251 modified "2023-10-05" @default.
- W2952568251 title "Synthesis and Analgesic Effects of 5-[4-(Arylpiperazin-1-yl)alkylamino]-4-benzyl-3-methyl-1,2-oxazin-6-ones" @default.
- W2952568251 doi "https://doi.org/10.1055/s-0031-1300214" @default.
- W2952568251 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10800634" @default.
- W2952568251 hasPublicationYear "2011" @default.
- W2952568251 type Work @default.
- W2952568251 sameAs 2952568251 @default.
- W2952568251 citedByCount "2" @default.
- W2952568251 crossrefType "journal-article" @default.
- W2952568251 hasAuthorship W2952568251A5013074392 @default.
- W2952568251 hasAuthorship W2952568251A5017594177 @default.
- W2952568251 hasAuthorship W2952568251A5019481950 @default.
- W2952568251 hasAuthorship W2952568251A5045046138 @default.
- W2952568251 hasAuthorship W2952568251A5057363669 @default.
- W2952568251 hasAuthorship W2952568251A5080352069 @default.
- W2952568251 hasConcept C126322002 @default.
- W2952568251 hasConcept C15490471 @default.
- W2952568251 hasConcept C170493617 @default.
- W2952568251 hasConcept C185592680 @default.
- W2952568251 hasConcept C197711040 @default.
- W2952568251 hasConcept C202751555 @default.
- W2952568251 hasConcept C2775864247 @default.
- W2952568251 hasConcept C2776754145 @default.
- W2952568251 hasConcept C2776885963 @default.
- W2952568251 hasConcept C2777389121 @default.
- W2952568251 hasConcept C2777676773 @default.
- W2952568251 hasConcept C2778750930 @default.
- W2952568251 hasConcept C2779004600 @default.
- W2952568251 hasConcept C2779134260 @default.
- W2952568251 hasConcept C2779734285 @default.
- W2952568251 hasConcept C2780304432 @default.
- W2952568251 hasConcept C2780820201 @default.
- W2952568251 hasConcept C2781063702 @default.
- W2952568251 hasConcept C37000724 @default.
- W2952568251 hasConcept C42533223 @default.
- W2952568251 hasConcept C55493867 @default.
- W2952568251 hasConcept C71240020 @default.
- W2952568251 hasConcept C71924100 @default.
- W2952568251 hasConcept C98274493 @default.
- W2952568251 hasConceptScore W2952568251C126322002 @default.
- W2952568251 hasConceptScore W2952568251C15490471 @default.
- W2952568251 hasConceptScore W2952568251C170493617 @default.
- W2952568251 hasConceptScore W2952568251C185592680 @default.
- W2952568251 hasConceptScore W2952568251C197711040 @default.
- W2952568251 hasConceptScore W2952568251C202751555 @default.
- W2952568251 hasConceptScore W2952568251C2775864247 @default.
- W2952568251 hasConceptScore W2952568251C2776754145 @default.
- W2952568251 hasConceptScore W2952568251C2776885963 @default.
- W2952568251 hasConceptScore W2952568251C2777389121 @default.
- W2952568251 hasConceptScore W2952568251C2777676773 @default.
- W2952568251 hasConceptScore W2952568251C2778750930 @default.
- W2952568251 hasConceptScore W2952568251C2779004600 @default.
- W2952568251 hasConceptScore W2952568251C2779134260 @default.
- W2952568251 hasConceptScore W2952568251C2779734285 @default.
- W2952568251 hasConceptScore W2952568251C2780304432 @default.
- W2952568251 hasConceptScore W2952568251C2780820201 @default.
- W2952568251 hasConceptScore W2952568251C2781063702 @default.
- W2952568251 hasConceptScore W2952568251C37000724 @default.
- W2952568251 hasConceptScore W2952568251C42533223 @default.
- W2952568251 hasConceptScore W2952568251C55493867 @default.
- W2952568251 hasConceptScore W2952568251C71240020 @default.
- W2952568251 hasConceptScore W2952568251C71924100 @default.
- W2952568251 hasConceptScore W2952568251C98274493 @default.
- W2952568251 hasIssue "04" @default.
- W2952568251 hasLocation W29525682511 @default.
- W2952568251 hasLocation W29525682512 @default.
- W2952568251 hasOpenAccess W2952568251 @default.
- W2952568251 hasPrimaryLocation W29525682511 @default.
- W2952568251 hasRelatedWork W1929097547 @default.
- W2952568251 hasRelatedWork W1986557319 @default.
- W2952568251 hasRelatedWork W1999890819 @default.
- W2952568251 hasRelatedWork W2007798656 @default.
- W2952568251 hasRelatedWork W2017741729 @default.
- W2952568251 hasRelatedWork W2040544575 @default.
- W2952568251 hasRelatedWork W2150242641 @default.
- W2952568251 hasRelatedWork W2952568251 @default.
- W2952568251 hasRelatedWork W4206871862 @default.
- W2952568251 hasRelatedWork W4287435042 @default.
- W2952568251 hasVolume "50" @default.
- W2952568251 isParatext "false" @default.
- W2952568251 isRetracted "false" @default.
- W2952568251 magId "2952568251" @default.
- W2952568251 workType "article" @default.