FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952577648> ?p ?o ?g. }

• W2952577648 endingPage "2107" @default.
• W2952577648 startingPage "2098" @default.
• W2952577648 abstract "Aims We aim to calculate 2 metrics of relative lethal toxicity; the fatal toxicity index (FTI; number of deaths per year of a daily dose) and the case fatality (CF; number of deaths per overdose) with a focus on opioids, antidepressants, antipsychotics, benzodiazepines and illicit drugs. Methods This descriptive cohort study used the Australian National Coronial Information System (NCIS) to identify a population of individuals with drug‐associated deaths in the Greater Newcastle Hunter Area between January 2002 and December 2016. This was combined with Australian medicine dispensing data and corresponding data from the Hunter Area Toxicology Service to calculate FTI and CF. Results There were 444 drug‐related deaths and 21,296 overdoses during the study period. FTI and CF were well correlated (Spearman's rho 0.64, P < .001). Of the classes of interest, opioids had the highest FTI (40.3 95% confidence interval [CI] 35.2–45.4 deaths per 100 years of use at the defined daily dose or deaths/DDD/100 years) and CF (12.4% 95%CI 11.0–13.9). Fentanyl, methadone and morphine had the highest relative fatal toxicity within this class. Tricyclic antidepressants had the highest relative fatal toxicity of all antidepressants (FTI 14.5 95%CI 9.7–19.3 deaths/DDD/100 years and CF 7.1% [95%CI 4.8–9.3]) and benzodiazepines appeared to be more associated with multiple agent deaths than single. Of the illicit drugs, heroin had the highest CF (26.4%, 95%CI 19.1–33.7). Conclusion Knowledge of relative lethal toxicity is useful to prescribers and medicines and public health policy makers in restricting access to more toxic drugs and may also assist coroners in determining cause of death." @default.
• W2952577648 created "2019-06-27" @default.
• W2952577648 creator A5004892177 @default.
• W2952577648 creator A5010907990 @default.
• W2952577648 creator A5040371388 @default.
• W2952577648 creator A5055738358 @default.
• W2952577648 creator A5090300123 @default.
• W2952577648 date "2019-07-17" @default.
• W2952577648 modified "2023-09-26" @default.
• W2952577648 title "The relative lethal toxicity of pharmaceutical and illicit substances: A 16‐year study of the Greater Newcastle Hunter Area, Australia" @default.
• W2952577648 cites W1514300820 @default.
• W2952577648 cites W1535347416 @default.
• W2952577648 cites W1898025493 @default.
• W2952577648 cites W1966305355 @default.
• W2952577648 cites W1983129192 @default.
• W2952577648 cites W1984573667 @default.
• W2952577648 cites W1989188195 @default.
• W2952577648 cites W1991575059 @default.
• W2952577648 cites W1994502737 @default.
• W2952577648 cites W1996546384 @default.
• W2952577648 cites W2005957833 @default.
• W2952577648 cites W2024238924 @default.
• W2952577648 cites W2039589642 @default.
• W2952577648 cites W2057756198 @default.
• W2952577648 cites W2060615806 @default.
• W2952577648 cites W2071742758 @default.
• W2952577648 cites W2076576215 @default.
• W2952577648 cites W2105958292 @default.
• W2952577648 cites W2120830237 @default.
• W2952577648 cites W2126704601 @default.
• W2952577648 cites W2148711098 @default.
• W2952577648 cites W2149437859 @default.
• W2952577648 cites W2150510046 @default.
• W2952577648 cites W2245353445 @default.
• W2952577648 cites W2288370485 @default.
• W2952577648 cites W2298818449 @default.
• W2952577648 cites W239922313 @default.
• W2952577648 cites W2411724849 @default.
• W2952577648 cites W2727888142 @default.
• W2952577648 cites W2741467355 @default.
• W2952577648 cites W2777791110 @default.
• W2952577648 cites W2781457855 @default.
• W2952577648 cites W2791854593 @default.
• W2952577648 cites W2802945045 @default.
• W2952577648 doi "https://doi.org/10.1111/bcp.14019" @default.
• W2952577648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6710517" @default.
• W2952577648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31173392" @default.
• W2952577648 hasPublicationYear "2019" @default.
• W2952577648 type Work @default.
• W2952577648 sameAs 2952577648 @default.
• W2952577648 citedByCount "18" @default.
• W2952577648 countsByYear W29525776482019 @default.
• W2952577648 countsByYear W29525776482020 @default.
• W2952577648 countsByYear W29525776482021 @default.
• W2952577648 countsByYear W29525776482022 @default.
• W2952577648 countsByYear W29525776482023 @default.
• W2952577648 crossrefType "journal-article" @default.
• W2952577648 hasAuthorship W2952577648A5004892177 @default.
• W2952577648 hasAuthorship W2952577648A5010907990 @default.
• W2952577648 hasAuthorship W2952577648A5040371388 @default.
• W2952577648 hasAuthorship W2952577648A5055738358 @default.
• W2952577648 hasAuthorship W2952577648A5090300123 @default.
• W2952577648 hasBestOaLocation W29525776481 @default.
• W2952577648 hasConcept C126322002 @default.
• W2952577648 hasConcept C2778903686 @default.
• W2952577648 hasConcept C2780035454 @default.
• W2952577648 hasConcept C2908647359 @default.
• W2952577648 hasConcept C29730261 @default.
• W2952577648 hasConcept C44249647 @default.
• W2952577648 hasConcept C71924100 @default.
• W2952577648 hasConcept C82789193 @default.
• W2952577648 hasConcept C98274493 @default.
• W2952577648 hasConcept C99454951 @default.
• W2952577648 hasConceptScore W2952577648C126322002 @default.
• W2952577648 hasConceptScore W2952577648C2778903686 @default.
• W2952577648 hasConceptScore W2952577648C2780035454 @default.
• W2952577648 hasConceptScore W2952577648C2908647359 @default.
• W2952577648 hasConceptScore W2952577648C29730261 @default.
• W2952577648 hasConceptScore W2952577648C44249647 @default.
• W2952577648 hasConceptScore W2952577648C71924100 @default.
• W2952577648 hasConceptScore W2952577648C82789193 @default.
• W2952577648 hasConceptScore W2952577648C98274493 @default.
• W2952577648 hasConceptScore W2952577648C99454951 @default.
• W2952577648 hasFunder F4320334705 @default.
• W2952577648 hasIssue "9" @default.
• W2952577648 hasLocation W29525776481 @default.
• W2952577648 hasLocation W29525776482 @default.
• W2952577648 hasOpenAccess W2952577648 @default.
• W2952577648 hasPrimaryLocation W29525776481 @default.
• W2952577648 hasRelatedWork W1975389766 @default.
• W2952577648 hasRelatedWork W1975636204 @default.
• W2952577648 hasRelatedWork W2028968031 @default.
• W2952577648 hasRelatedWork W2042119042 @default.
• W2952577648 hasRelatedWork W2072233267 @default.
• W2952577648 hasRelatedWork W2083188054 @default.
• W2952577648 hasRelatedWork W2134082182 @default.
• W2952577648 hasRelatedWork W2316007655 @default.
• W2952577648 hasRelatedWork W2893837634 @default.

• next