Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952578462> ?p ?o ?g. }
- W2952578462 abstract "Eukaryotic genes generate multiple mRNA transcript isoforms though alternative transcription, splicing, and polyadenylation. However, the relationship between human transcript diversity and protein production is complex as each isoform can be translated differently. We fractionated a polysome profile and reconstructed transcript isoforms from each fraction, which we term Transcript Isoforms in Polysomes sequencing (TrIP-seq). Analysis of these data revealed regulatory features that control ribosome occupancy and translational output of each transcript isoform. We extracted a panel of 5′ and 3′ untranslated regions that control protein production from an unrelated gene in cells over a 100-fold range. Select 5′ untranslated regions exert robust translational control between cell lines, while 3′ untranslated regions can confer cell-type-specific expression. These results expose the large dynamic range of transcript-isoform-specific translational control, identify isoform-specific sequences that control protein output in human cells, and demonstrate that transcript isoform diversity must be considered when relating RNA and protein levels." @default.
- W2952578462 created "2019-06-27" @default.
- W2952578462 creator A5067184382 @default.
- W2952578462 creator A5070694454 @default.
- W2952578462 date "2015-12-23" @default.
- W2952578462 modified "2023-09-23" @default.
- W2952578462 title "Tunable protein synthesis by transcript isoforms in human cells" @default.
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