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- W2952585772 abstract "Squalene-hopene cyclase (SHC) is a useful model enzyme for predicting molecular interactions with oxidosqualene cyclase (OSC). Structure–activity relationships were investigated for numerous coumarin-derived inhibitors of SHC, and structural simplifications are suggested. Both umbelliferone and 2,4-dihydroxyacetophenone provide convenient starting nuclei for the design of SHC inhibitors. Derivatives bearing an ω-epoxyfarnesyl moiety or just a plain alkyl chain showed an inhibitory effect on a recombinant SHC from Alicyclobacillus acidocaldarius expressed in Escherichia coli." @default.
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- W2952585772 date "2005-03-29" @default.
- W2952585772 modified "2023-10-16" @default.
- W2952585772 title "Novel Squalene-Hopene Cyclase Inhibitors Derived from Hydroxycoumarins and Hydroxyacetophenones." @default.
- W2952585772 cites W2110774536 @default.
- W2952585772 doi "https://doi.org/10.1002/chin.200513150" @default.
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