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- W2952592783 abstract "Abstract The use of CRISPR-Cas9 as a therapeutic reagent is hampered by its off-target effects. Although rationally designed S. pyogenes Cas9 (SpCas9) variants that display higher specificities than the wild-type SpCas9 protein are available, these attenuated Cas9 variants are often poorly efficient in human cells. Here, we have used a directed evolution approach in E. coli to obtain Sniper-Cas9, which shows high specificities without sacrificing on-target activities in human cells." @default.
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- W2952592783 date "2017-12-19" @default.
- W2952592783 modified "2023-09-27" @default.
- W2952592783 title "Directed evolution of CRISPR-Cas9 to increase its specificity" @default.
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- W2952592783 doi "https://doi.org/10.1101/237040" @default.
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