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- W2952594471 abstract "Signal peptides are short peptides directing newly synthesized proteins toward the secretory pathway. These N-terminal signal sequences are ubiquitous to all prokaryotes and eukaryotes. Signal peptides play a significant role in recombinant protein production. Previous studies have demonstrated that the secretion amount of a given target protein varies significantly depending on the signal peptide that is fused to the protein. Signal peptide selection and signal peptide modification are the two main methods for the optimization of a recombinant protein secretion. However, the highly efficient signal peptide for a target protein with a specific bacterial expression host is not predictable so far. In this article, we collect several signal peptides that have previously performed well for recombinant protein secretion in gram-positive bacteria. We also discuss several factors influencing recombinant protein secretion efficiency in gram-positive bacteria. Signal peptides with a higher charge/length ratio in n-region, more consensus residues at the-3 and-1positions in c-region and a much higher proportion of coils are more likely to perform well in the secretion of recombinant proteins. These summaries can be utilized to the selection and directed modification of signal peptides for a given recombinant protein." @default.
- W2952594471 created "2019-06-27" @default.
- W2952594471 creator A5001804966 @default.
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- W2952594471 creator A5031084065 @default.
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- W2952594471 creator A5079587295 @default.
- W2952594471 date "2019-06-11" @default.
- W2952594471 modified "2023-10-12" @default.
- W2952594471 title "Factors Influencing Recombinant Protein Secretion Efficiency in Gram-Positive Bacteria: Signal Peptide and Beyond" @default.
- W2952594471 cites W1607150245 @default.
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- W2952594471 cites W1935158889 @default.
- W2952594471 cites W1975304761 @default.
- W2952594471 cites W1976221987 @default.
- W2952594471 cites W2000181858 @default.
- W2952594471 cites W2002298198 @default.
- W2952594471 cites W2002443564 @default.
- W2952594471 cites W2004377868 @default.
- W2952594471 cites W2014584269 @default.
- W2952594471 cites W2018018465 @default.
- W2952594471 cites W2020091849 @default.
- W2952594471 cites W2027831935 @default.
- W2952594471 cites W2038605297 @default.
- W2952594471 cites W2045985595 @default.
- W2952594471 cites W2046083957 @default.
- W2952594471 cites W2051228958 @default.
- W2952594471 cites W2061385538 @default.
- W2952594471 cites W2066804008 @default.
- W2952594471 cites W2073075045 @default.
- W2952594471 cites W2074664766 @default.
- W2952594471 cites W2075931870 @default.
- W2952594471 cites W2085338944 @default.
- W2952594471 cites W2090574716 @default.
- W2952594471 cites W2094201044 @default.
- W2952594471 cites W2095970056 @default.
- W2952594471 cites W2096217709 @default.
- W2952594471 cites W2105986552 @default.
- W2952594471 cites W2108575112 @default.
- W2952594471 cites W2111086397 @default.
- W2952594471 cites W2111440671 @default.
- W2952594471 cites W2111712628 @default.
- W2952594471 cites W2116788456 @default.
- W2952594471 cites W2120340514 @default.
- W2952594471 cites W2124088653 @default.
- W2952594471 cites W2126896559 @default.
- W2952594471 cites W2129560957 @default.
- W2952594471 cites W2132192325 @default.
- W2952594471 cites W2146923243 @default.
- W2952594471 cites W2148334906 @default.
- W2952594471 cites W2149649966 @default.
- W2952594471 cites W2153635508 @default.
- W2952594471 cites W2154243627 @default.
- W2952594471 cites W2157815481 @default.
- W2952594471 cites W2158266834 @default.
- W2952594471 cites W2164751980 @default.
- W2952594471 cites W2168733752 @default.
- W2952594471 cites W2173346107 @default.
- W2952594471 cites W2188104093 @default.
- W2952594471 cites W2252135438 @default.
- W2952594471 cites W2289658572 @default.
- W2952594471 cites W2308145610 @default.
- W2952594471 cites W2332848608 @default.
- W2952594471 cites W233560767 @default.
- W2952594471 cites W2346633676 @default.
- W2952594471 cites W2406540431 @default.
- W2952594471 cites W2414110281 @default.
- W2952594471 cites W2474908756 @default.
- W2952594471 cites W2552612734 @default.
- W2952594471 cites W2559192784 @default.
- W2952594471 cites W2559870726 @default.
- W2952594471 cites W2560636839 @default.
- W2952594471 cites W2589075172 @default.
- W2952594471 cites W2613156048 @default.
- W2952594471 cites W2618467927 @default.
- W2952594471 cites W2767638256 @default.
- W2952594471 cites W2770889773 @default.
- W2952594471 cites W2794306218 @default.
- W2952594471 cites W2802730096 @default.
- W2952594471 cites W2809247618 @default.
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- W2952594471 doi "https://doi.org/10.3389/fbioe.2019.00139" @default.
- W2952594471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6579943" @default.
- W2952594471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31245367" @default.
- W2952594471 hasPublicationYear "2019" @default.
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