Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952597906> ?p ?o ?g. }
- W2952597906 endingPage "668" @default.
- W2952597906 startingPage "655" @default.
- W2952597906 abstract "Oxidative stress accompanying excessive accumulation of reactive oxygen species (ROS) and mitochondrial dysfunction leads to the occurrence of neurodegenerative diseases. Our previous study showed that Eclalbasaponin I (EcI), a triterpene saponin isolated from Aralia elata (Miq.) Seem. (A. elata), repressed oxidative stress in human neuroblastoma SH-SY5Y cells. However, the detailed mechanism remains unclear. In this study, pretreatment with EcI in SH-SY5Y cells significantly activated the p38-mitogenactivated protein kinase (p38), the extracellular regulated protein kinase (ERK), whereas it did not affect the c-jun NH2 terminal kinases (JNK). In accordance with the initial findings, EcI-induced neuroprotective effect was attenuated by SB203580 (SB, a p38 inhibitor) or FR180204 (FR, an ERK inhibitor), being further confirmed by specific small interfering RNA (siRNA). Inhibition of either p38 or ERK up-regulated the apoptosis induction in EcI- and H2O2-cotreated cells. Furthermore, p38 or ERK suppression enhanced intracellular and mitochondrial ROS generation, decreased the activities of endogenous antioxidant defences as well as the mitochondrial membrane potential (MMP), resulting in dysfunction of mitochondria. In addition, EcI-induced autophagy and mitophagy were obviously down-regulated when p38 or ERK activation was blocked. Cumulatively, these findings supported that EcI-caused mitophagy contributed to the neuroprotective effect through p38 or ERK activation. Mitophagy induction might be an effective therapeutic intervention in neurodegenerative diseases." @default.
- W2952597906 created "2019-06-27" @default.
- W2952597906 creator A5022941728 @default.
- W2952597906 creator A5046597133 @default.
- W2952597906 creator A5062668196 @default.
- W2952597906 creator A5065236570 @default.
- W2952597906 creator A5068859843 @default.
- W2952597906 creator A5069771785 @default.
- W2952597906 creator A5086664284 @default.
- W2952597906 creator A5088860681 @default.
- W2952597906 date "2019-06-03" @default.
- W2952597906 modified "2023-09-28" @default.
- W2952597906 title "Eclalbasaponin I causes mitophagy to repress oxidative stress-induced apoptosis via activation of p38 and ERK in SH-SY5Y cells" @default.
- W2952597906 cites W1510592624 @default.
- W2952597906 cites W1971620525 @default.
- W2952597906 cites W1992361007 @default.
- W2952597906 cites W1994823455 @default.
- W2952597906 cites W2014242912 @default.
- W2952597906 cites W2023416053 @default.
- W2952597906 cites W2040462743 @default.
- W2952597906 cites W2082425146 @default.
- W2952597906 cites W2084472730 @default.
- W2952597906 cites W2089082011 @default.
- W2952597906 cites W2097724095 @default.
- W2952597906 cites W2142416302 @default.
- W2952597906 cites W2203559153 @default.
- W2952597906 cites W2262295873 @default.
- W2952597906 cites W2265424409 @default.
- W2952597906 cites W2281499398 @default.
- W2952597906 cites W2335833703 @default.
- W2952597906 cites W2404561274 @default.
- W2952597906 cites W2414229810 @default.
- W2952597906 cites W2516250333 @default.
- W2952597906 cites W2517107066 @default.
- W2952597906 cites W2529600492 @default.
- W2952597906 cites W2547689139 @default.
- W2952597906 cites W2548419511 @default.
- W2952597906 cites W2566971122 @default.
- W2952597906 cites W2587554899 @default.
- W2952597906 cites W2596895204 @default.
- W2952597906 cites W2621362905 @default.
- W2952597906 cites W2624493696 @default.
- W2952597906 cites W2738548489 @default.
- W2952597906 cites W2748521921 @default.
- W2952597906 cites W2748539286 @default.
- W2952597906 cites W2752420967 @default.
- W2952597906 cites W2755718135 @default.
- W2952597906 cites W2756737950 @default.
- W2952597906 cites W2765451325 @default.
- W2952597906 cites W2767392461 @default.
- W2952597906 cites W2780891616 @default.
- W2952597906 cites W2783967054 @default.
- W2952597906 cites W2795996015 @default.
- W2952597906 cites W2801147510 @default.
- W2952597906 cites W2802998522 @default.
- W2952597906 doi "https://doi.org/10.1080/10715762.2019.1620937" @default.
- W2952597906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31185752" @default.
- W2952597906 hasPublicationYear "2019" @default.
- W2952597906 type Work @default.
- W2952597906 sameAs 2952597906 @default.
- W2952597906 citedByCount "7" @default.
- W2952597906 countsByYear W29525979062019 @default.
- W2952597906 countsByYear W29525979062020 @default.
- W2952597906 countsByYear W29525979062021 @default.
- W2952597906 countsByYear W29525979062022 @default.
- W2952597906 countsByYear W29525979062023 @default.
- W2952597906 crossrefType "journal-article" @default.
- W2952597906 hasAuthorship W2952597906A5022941728 @default.
- W2952597906 hasAuthorship W2952597906A5046597133 @default.
- W2952597906 hasAuthorship W2952597906A5062668196 @default.
- W2952597906 hasAuthorship W2952597906A5065236570 @default.
- W2952597906 hasAuthorship W2952597906A5068859843 @default.
- W2952597906 hasAuthorship W2952597906A5069771785 @default.
- W2952597906 hasAuthorship W2952597906A5086664284 @default.
- W2952597906 hasAuthorship W2952597906A5088860681 @default.
- W2952597906 hasBestOaLocation W29525979062 @default.
- W2952597906 hasConcept C184235292 @default.
- W2952597906 hasConcept C185592680 @default.
- W2952597906 hasConcept C190283241 @default.
- W2952597906 hasConcept C203522944 @default.
- W2952597906 hasConcept C25498285 @default.
- W2952597906 hasConcept C2776151105 @default.
- W2952597906 hasConcept C2776715637 @default.
- W2952597906 hasConcept C2778175917 @default.
- W2952597906 hasConcept C2779083432 @default.
- W2952597906 hasConcept C2779324830 @default.
- W2952597906 hasConcept C48349386 @default.
- W2952597906 hasConcept C51551487 @default.
- W2952597906 hasConcept C54355233 @default.
- W2952597906 hasConcept C55493867 @default.
- W2952597906 hasConcept C57074206 @default.
- W2952597906 hasConcept C81885089 @default.
- W2952597906 hasConcept C86803240 @default.
- W2952597906 hasConcept C95444343 @default.
- W2952597906 hasConcept C98274493 @default.
- W2952597906 hasConceptScore W2952597906C184235292 @default.
- W2952597906 hasConceptScore W2952597906C185592680 @default.
- W2952597906 hasConceptScore W2952597906C190283241 @default.