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- W295260312 abstract "The mechanisms by which cells destabilize and rapidly disassemble filamentous actin networks have remained elusive; however, Coronin, Cofilin and AIP1 have been implicated in this process. Here using multi-wavelength single-molecule fluorescence imaging, we show that mammalian Cor1B, Cof1 and AIP1 work in concert through a temporally ordered pathway to induce highly efficient severing and disassembly of actin filaments. Cor1B binds to filaments first, and dramatically accelerates the subsequent binding of Cof1, leading to heavily decorated, stabilized filaments. Cof1 in turn recruits AIP1, which rapidly triggers severing and remains bound to the newly generated barbed ends. New growth at barbed ends generated by severing was blocked specifically in the presence of all three proteins. This activity enabled us to reconstitute and directly visualize single actin filaments being rapidly polymerized by formins at their barbed ends while simultanteously being stochastically severed and capped along their lengths, and disassembled from their pointed ends." @default.
- W295260312 created "2016-06-24" @default.
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- W295260312 date "2015-05-21" @default.
- W295260312 modified "2023-10-05" @default.
- W295260312 title "Single-molecule imaging of a three-component ordered actin disassembly mechanism" @default.
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- W295260312 doi "https://doi.org/10.1038/ncomms8202" @default.
- W295260312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4443854" @default.
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