FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952607907> ?p ?o ?g. }

• W2952607907 endingPage "932" @default.
• W2952607907 startingPage "925" @default.
• W2952607907 abstract "Because it is difficult to achieve local drug activity following administration by the conventional intravenous and oral routes, I sought to develop a new route of administration utilizing drug absorption from the liver surface in order to target that organ. Although direct application to the liver surface should yield local drug distribution, drug absorption from the liver surface has not been reported in the literature. Therefore, we analyzed, as a model, the efficiency of absorption of several organic anions and dextrans of various molecular weights following application to the rat liver surface in vivo using a cylindrical diffusion cell. Each compound appeared gradually in the plasma, followed by excretion into the bile and/or urine, indicating the possibility of drug absorption from the liver surface. The absorption process from the liver surface may not involve a specific transport system because dose and transport inhibitors had no detectable effect. In addition, molecular weight was found to be a determinant of absorption through the liver surface. The efficiency of targeting desired region in the liver was enhanced considerably by application to the liver surface, compared to intravenous administration. Moreover, I have obtained several promising results from the application of this new drug delivery system to anticancer drugs and gene therapy. On the other hand, I have also clarified the characteristics of drug absorption from the surfaces of the kidney, stomach, cecum and small intestine, and plan to apply the physiological findings to other fields." @default.
• W2952607907 created "2019-06-27" @default.
• W2952607907 creator A5061258543 @default.
• W2952607907 date "2009-08-01" @default.
• W2952607907 modified "2023-10-14" @default.
• W2952607907 title "Development of Drug Delivery System by Utilizing Absorption from Liver Surface and Its Application" @default.
• W2952607907 cites W1897698180 @default.
• W2952607907 cites W1968628281 @default.
• W2952607907 cites W1975578482 @default.
• W2952607907 cites W1978155760 @default.
• W2952607907 cites W1980110865 @default.
• W2952607907 cites W1989858269 @default.
• W2952607907 cites W1998413876 @default.
• W2952607907 cites W1999785096 @default.
• W2952607907 cites W2000573426 @default.
• W2952607907 cites W2004255132 @default.
• W2952607907 cites W2014303784 @default.
• W2952607907 cites W2022387111 @default.
• W2952607907 cites W2031393553 @default.
• W2952607907 cites W2033283679 @default.
• W2952607907 cites W2035095058 @default.
• W2952607907 cites W2036365578 @default.
• W2952607907 cites W2047172201 @default.
• W2952607907 cites W2051948055 @default.
• W2952607907 cites W2051953242 @default.
• W2952607907 cites W2052588699 @default.
• W2952607907 cites W2052755604 @default.
• W2952607907 cites W2057196510 @default.
• W2952607907 cites W2057312851 @default.
• W2952607907 cites W2088178738 @default.
• W2952607907 cites W2090103031 @default.
• W2952607907 cites W2093725375 @default.
• W2952607907 cites W2093820440 @default.
• W2952607907 cites W2094137249 @default.
• W2952607907 cites W2098716812 @default.
• W2952607907 cites W2103082009 @default.
• W2952607907 cites W2109291833 @default.
• W2952607907 cites W2115651830 @default.
• W2952607907 cites W2127369173 @default.
• W2952607907 cites W2152858879 @default.
• W2952607907 cites W2224010948 @default.
• W2952607907 cites W2313476872 @default.
• W2952607907 cites W2321978023 @default.
• W2952607907 cites W2418118550 @default.
• W2952607907 cites W281772579 @default.
• W2952607907 doi "https://doi.org/10.1248/yakushi.129.925" @default.
• W2952607907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19652498" @default.
• W2952607907 hasPublicationYear "2009" @default.
• W2952607907 type Work @default.
• W2952607907 sameAs 2952607907 @default.
• W2952607907 citedByCount "1" @default.
• W2952607907 crossrefType "journal-article" @default.
• W2952607907 hasAuthorship W2952607907A5061258543 @default.
• W2952607907 hasBestOaLocation W29526079071 @default.
• W2952607907 hasConcept C112705442 @default.
• W2952607907 hasConcept C125287762 @default.
• W2952607907 hasConcept C150903083 @default.
• W2952607907 hasConcept C159985019 @default.
• W2952607907 hasConcept C178790620 @default.
• W2952607907 hasConcept C185592680 @default.
• W2952607907 hasConcept C192562407 @default.
• W2952607907 hasConcept C207001950 @default.
• W2952607907 hasConcept C2777882243 @default.
• W2952607907 hasConcept C2779820397 @default.
• W2952607907 hasConcept C2780035454 @default.
• W2952607907 hasConcept C55493867 @default.
• W2952607907 hasConcept C71924100 @default.
• W2952607907 hasConcept C86803240 @default.
• W2952607907 hasConcept C98274493 @default.
• W2952607907 hasConceptScore W2952607907C112705442 @default.
• W2952607907 hasConceptScore W2952607907C125287762 @default.
• W2952607907 hasConceptScore W2952607907C150903083 @default.
• W2952607907 hasConceptScore W2952607907C159985019 @default.
• W2952607907 hasConceptScore W2952607907C178790620 @default.
• W2952607907 hasConceptScore W2952607907C185592680 @default.
• W2952607907 hasConceptScore W2952607907C192562407 @default.
• W2952607907 hasConceptScore W2952607907C207001950 @default.
• W2952607907 hasConceptScore W2952607907C2777882243 @default.
• W2952607907 hasConceptScore W2952607907C2779820397 @default.
• W2952607907 hasConceptScore W2952607907C2780035454 @default.
• W2952607907 hasConceptScore W2952607907C55493867 @default.
• W2952607907 hasConceptScore W2952607907C71924100 @default.
• W2952607907 hasConceptScore W2952607907C86803240 @default.
• W2952607907 hasConceptScore W2952607907C98274493 @default.
• W2952607907 hasIssue "8" @default.
• W2952607907 hasLocation W29526079071 @default.
• W2952607907 hasLocation W29526079072 @default.
• W2952607907 hasOpenAccess W2952607907 @default.
• W2952607907 hasPrimaryLocation W29526079071 @default.
• W2952607907 hasRelatedWork W1491964893 @default.
• W2952607907 hasRelatedWork W1990414540 @default.
• W2952607907 hasRelatedWork W2004556784 @default.
• W2952607907 hasRelatedWork W2029351008 @default.
• W2952607907 hasRelatedWork W2094219250 @default.
• W2952607907 hasRelatedWork W2378945660 @default.
• W2952607907 hasRelatedWork W2379311614 @default.
• W2952607907 hasRelatedWork W2388069209 @default.
• W2952607907 hasRelatedWork W2582907174 @default.

• next