FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952625607> ?p ?o ?g. }

• W2952625607 abstract "Ethanol withdrawal (EtOHW) anxiety is a crucial risk factor for alcoholic relapse. The neuropeptide nociceptin/orphanin FQ (N/OFQ) acts upon its receptor (NOP) to antagonize corticotropin-releasing factor (CRF) and elicit anxiolytic actions. Semen Ziziphi Spinosae (SZS), a prototypical hypnotic-sedative herb in Oriental medicine, exhibits anxiolytic effects during nicotine withdrawal by improving amygdaloid CRF/CRF1 receptor (CRFR1) signaling. Therefore, we evaluated the effects of SZS on EtOHW anxiety and the involvement of amygdaloid CRF/CRFR1 and N/OFQ/NOP pathways. Male Sprague Dawley rats received intraperitoneal injections of 2 g/kg EtOH (20% v/v) once daily for 28 d followed by a 3-d withdrawal. During EtOHW, the rats were given once-daily intragastric treatments of a methanol extract of SZS (MESZS, 60 or 180 mg/kg/d). Anxiety-like behaviors were measured with the open field (OF) and elevated plus maze (EPM) tests, and plasma corticosterone (CORT) levels were examined by an enzyme-linked immunosorbent assay. mRNA and protein expression levels of the neuropeptides and their receptors were determined by quantitative polymerase chain reaction and Western blot assays. MESZS increased the distance traveled in the center zone of the OF and dose-dependently elongated the duration of staying in the center zone in EtOHW rats. MESZS increased both the number of entries into and the time spent in the open arms of the EPM by EtOHW rats. And, MESZS inhibited the over secretion of plasma CORT during EtOHW. EtOHW enhanced CRF and CRFR1 gene and protein expression in the central nucleus of the amygdala (CeA), which were inhibited by 180 mg/kg/d MESZS. EtOHW increased amygdaloid NOP mRNA and protein expression but spared N/OFQ mRNA expression, and 180 mg/kg/d MESZS further promoted these increases. Additionally, a post-MESZS intra-CeA infusion of either CRF or the selective NOP antagonist UFP-101 abolished the expected anxiolytic effect of 180 mg/kg/d MESZS. These results suggest that MESZS ameliorates EtOHW anxiety by improving both CRF/CRFR1 and N/OFQ/NOP transmissions in the CeA." @default.
• W2952625607 created "2019-06-27" @default.
• W2952625607 creator A5017258526 @default.
• W2952625607 creator A5018460590 @default.
• W2952625607 creator A5018809080 @default.
• W2952625607 creator A5021682888 @default.
• W2952625607 creator A5035244008 @default.
• W2952625607 creator A5041110713 @default.
• W2952625607 creator A5042227235 @default.
• W2952625607 creator A5049279379 @default.
• W2952625607 creator A5057974687 @default.
• W2952625607 creator A5064584432 @default.
• W2952625607 creator A5066302961 @default.
• W2952625607 creator A5072871545 @default.
• W2952625607 creator A5076132049 @default.
• W2952625607 creator A5079511014 @default.
• W2952625607 creator A5087784825 @default.
• W2952625607 date "2019-06-24" @default.
• W2952625607 modified "2023-10-15" @default.
• W2952625607 title "Methanol extract of semen Ziziphi Spinosae attenuates ethanol withdrawal anxiety by improving neuropeptide signaling in the central amygdala" @default.
• W2952625607 cites W1517689773 @default.
• W2952625607 cites W1543912755 @default.
• W2952625607 cites W1571457776 @default.
• W2952625607 cites W1905094938 @default.
• W2952625607 cites W1927728226 @default.
• W2952625607 cites W1966071951 @default.
• W2952625607 cites W1967138211 @default.
• W2952625607 cites W1972870562 @default.
• W2952625607 cites W1974486928 @default.
• W2952625607 cites W1976175578 @default.
• W2952625607 cites W1979383422 @default.
• W2952625607 cites W1982866514 @default.
• W2952625607 cites W1983708315 @default.
• W2952625607 cites W1989915552 @default.
• W2952625607 cites W2001005368 @default.
• W2952625607 cites W2002153331 @default.
• W2952625607 cites W2010827811 @default.
• W2952625607 cites W2011041824 @default.
• W2952625607 cites W2012008651 @default.
• W2952625607 cites W2015738565 @default.
• W2952625607 cites W2016770860 @default.
• W2952625607 cites W2017495352 @default.
• W2952625607 cites W2018303025 @default.
• W2952625607 cites W2018571651 @default.
• W2952625607 cites W2024063445 @default.
• W2952625607 cites W2034205729 @default.
• W2952625607 cites W2047039000 @default.
• W2952625607 cites W2047197211 @default.
• W2952625607 cites W2064342896 @default.
• W2952625607 cites W2064623714 @default.
• W2952625607 cites W2065201158 @default.
• W2952625607 cites W2067306449 @default.
• W2952625607 cites W2068015354 @default.
• W2952625607 cites W2068124159 @default.
• W2952625607 cites W2069946469 @default.
• W2952625607 cites W2074826561 @default.
• W2952625607 cites W2078974273 @default.
• W2952625607 cites W2080894664 @default.
• W2952625607 cites W2085747860 @default.
• W2952625607 cites W2098001295 @default.
• W2952625607 cites W2103315882 @default.
• W2952625607 cites W2125837141 @default.
• W2952625607 cites W2130325363 @default.
• W2952625607 cites W2147534602 @default.
• W2952625607 cites W2164614031 @default.
• W2952625607 cites W2313182721 @default.
• W2952625607 cites W2324677701 @default.
• W2952625607 cites W2405460636 @default.
• W2952625607 cites W2528156728 @default.
• W2952625607 cites W2604515279 @default.
• W2952625607 cites W2609907394 @default.
• W2952625607 cites W2730054638 @default.
• W2952625607 cites W2889187997 @default.
• W2952625607 cites W4322703284 @default.
• W2952625607 cites W59468650 @default.
• W2952625607 doi "https://doi.org/10.1186/s12906-019-2546-0" @default.
• W2952625607 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6591875" @default.
• W2952625607 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31234859" @default.
• W2952625607 hasPublicationYear "2019" @default.
• W2952625607 type Work @default.
• W2952625607 sameAs 2952625607 @default.
• W2952625607 citedByCount "8" @default.
• W2952625607 countsByYear W29526256072020 @default.
• W2952625607 countsByYear W29526256072021 @default.
• W2952625607 countsByYear W29526256072022 @default.
• W2952625607 countsByYear W29526256072023 @default.
• W2952625607 crossrefType "journal-article" @default.
• W2952625607 hasAuthorship W2952625607A5017258526 @default.
• W2952625607 hasAuthorship W2952625607A5018460590 @default.
• W2952625607 hasAuthorship W2952625607A5018809080 @default.
• W2952625607 hasAuthorship W2952625607A5021682888 @default.
• W2952625607 hasAuthorship W2952625607A5035244008 @default.
• W2952625607 hasAuthorship W2952625607A5041110713 @default.
• W2952625607 hasAuthorship W2952625607A5042227235 @default.
• W2952625607 hasAuthorship W2952625607A5049279379 @default.
• W2952625607 hasAuthorship W2952625607A5057974687 @default.
• W2952625607 hasAuthorship W2952625607A5064584432 @default.
• W2952625607 hasAuthorship W2952625607A5066302961 @default.
• W2952625607 hasAuthorship W2952625607A5072871545 @default.
• W2952625607 hasAuthorship W2952625607A5076132049 @default.

• next