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- W2952625910 abstract "Author(s): Dong, Meimei | Advisor(s): Groves, Jay T | Abstract: EphB4 receptor tyrosine kinases bind and cluster with membrane bound ephrinB2 ligands on apposing cells to signal juxtacrine. While this signal activation plays a regulatory role in neural stem cell differentiation, the underlying biophysical mechanism remains poorly understood. We reconstituted this juxtacrine signalling geometry between live EphB4-expressing neural stem cells and a supported lipid bilayer presenting laterally mobile monomeric ephrinB2 ligands. A novel method was developed to study neural stem cell differentiation by this hybrid system. This setup allows for observations of the timescale and spatial distribution of receptor-ligand binding and clustering. Furthermore, it accommodates the method of spatial mutation—whereby physical constraints are imposed by lithographically patterned micro-corrals—to restrict EphB4 receptor mobility and precisely control the spatial patterns of receptor-ligand organisation. We found that this physical reorganisation of EphB4-ephrinB2 inhibits neuronal differentiation, suggesting spatial and mechanical sensing of EphB4 signalling in neural stem cells." @default.
- W2952625910 created "2019-06-27" @default.
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- W2952625910 date "2015-01-01" @default.
- W2952625910 modified "2023-09-28" @default.
- W2952625910 title "Spatial and Mechanical Regulation of EphB Receptor in Neural Stem Cell Function" @default.
- W2952625910 hasPublicationYear "2015" @default.
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