FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952628721> ?p ?o ?g. }

• W2952628721 abstract "Characterizing complex viral transcriptomes by conventional RNA sequencing approaches is complicated by high gene density, overlapping reading frames, and complex splicing patterns. Direct RNA sequencing (direct RNA-seq) using nanopore arrays offers an exciting alternative whereby individual polyadenylated RNAs are sequenced directly, without the recoding and amplification biases inherent to other sequencing methodologies. Here we use direct RNA-seq to profile the herpes simplex virus type 1 (HSV-1) transcriptome during productive infection of primary cells. We show how direct RNA-seq data can be used to define transcription initiation and RNA cleavage sites associated with all polyadenylated viral RNAs and demonstrate that low level read-through transcription produces a novel class of chimeric HSV-1 transcripts, including a functional mRNA encoding a fusion of the viral E3 ubiquitin ligase ICP0 and viral membrane glycoprotein L. Thus, direct RNA-seq offers a powerful method to characterize the changing transcriptional landscape of viruses with complex genomes." @default.
• W2952628721 created "2019-06-27" @default.
• W2952628721 creator A5031017599 @default.
• W2952628721 creator A5034902241 @default.
• W2952628721 creator A5036289658 @default.
• W2952628721 creator A5055851463 @default.
• W2952628721 creator A5057087207 @default.
• W2952628721 creator A5071564673 @default.
• W2952628721 creator A5079066606 @default.
• W2952628721 creator A5084892222 @default.
• W2952628721 date "2019-02-14" @default.
• W2952628721 modified "2023-10-11" @default.
• W2952628721 title "Direct RNA sequencing on nanopore arrays redefines the transcriptional complexity of a viral pathogen" @default.
• W2952628721 cites W1519422934 @default.
• W2952628721 cites W1540296073 @default.
• W2952628721 cites W1970010476 @default.
• W2952628721 cites W1992308820 @default.
• W2952628721 cites W2004463564 @default.
• W2952628721 cites W2005401328 @default.
• W2952628721 cites W2010005720 @default.
• W2952628721 cites W2021341670 @default.
• W2952628721 cites W2024915066 @default.
• W2952628721 cites W2042726596 @default.
• W2952628721 cites W2055043387 @default.
• W2952628721 cites W2077132193 @default.
• W2952628721 cites W2080611052 @default.
• W2952628721 cites W2098809361 @default.
• W2952628721 cites W2102619694 @default.
• W2952628721 cites W2103851463 @default.
• W2952628721 cites W2105879579 @default.
• W2952628721 cites W2108234281 @default.
• W2952628721 cites W2111397517 @default.
• W2952628721 cites W2119376048 @default.
• W2952628721 cites W2125137658 @default.
• W2952628721 cites W2129129906 @default.
• W2952628721 cites W2131478115 @default.
• W2952628721 cites W2136660710 @default.
• W2952628721 cites W2139306346 @default.
• W2952628721 cites W2140938255 @default.
• W2952628721 cites W2157107905 @default.
• W2952628721 cites W2165093251 @default.
• W2952628721 cites W2169352485 @default.
• W2952628721 cites W2203588018 @default.
• W2952628721 cites W2294086086 @default.
• W2952628721 cites W2398730115 @default.
• W2952628721 cites W2411397641 @default.
• W2952628721 cites W2415553065 @default.
• W2952628721 cites W2467179929 @default.
• W2952628721 cites W2583377988 @default.
• W2952628721 cites W2592218525 @default.
• W2952628721 cites W2599935497 @default.
• W2952628721 cites W2601106856 @default.
• W2952628721 cites W2623595296 @default.
• W2952628721 cites W2688344404 @default.
• W2952628721 cites W2746992081 @default.
• W2952628721 cites W2765207587 @default.
• W2952628721 cites W2765375908 @default.
• W2952628721 cites W2786800336 @default.
• W2952628721 cites W2789843538 @default.
• W2952628721 cites W2791571516 @default.
• W2952628721 cites W2804913968 @default.
• W2952628721 cites W2808130319 @default.
• W2952628721 cites W2890852354 @default.
• W2952628721 cites W2903793577 @default.
• W2952628721 cites W2950063384 @default.
• W2952628721 cites W2953020124 @default.
• W2952628721 doi "https://doi.org/10.1038/s41467-019-08734-9" @default.
• W2952628721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6376126" @default.
• W2952628721 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30765700" @default.
• W2952628721 hasPublicationYear "2019" @default.
• W2952628721 type Work @default.
• W2952628721 sameAs 2952628721 @default.
• W2952628721 citedByCount "165" @default.
• W2952628721 countsByYear W29526287212019 @default.
• W2952628721 countsByYear W29526287212020 @default.
• W2952628721 countsByYear W29526287212021 @default.
• W2952628721 countsByYear W29526287212022 @default.
• W2952628721 countsByYear W29526287212023 @default.
• W2952628721 crossrefType "journal-article" @default.
• W2952628721 hasAuthorship W2952628721A5031017599 @default.
• W2952628721 hasAuthorship W2952628721A5034902241 @default.
• W2952628721 hasAuthorship W2952628721A5036289658 @default.
• W2952628721 hasAuthorship W2952628721A5055851463 @default.
• W2952628721 hasAuthorship W2952628721A5057087207 @default.
• W2952628721 hasAuthorship W2952628721A5071564673 @default.
• W2952628721 hasAuthorship W2952628721A5079066606 @default.
• W2952628721 hasAuthorship W2952628721A5084892222 @default.
• W2952628721 hasBestOaLocation W29526287211 @default.
• W2952628721 hasConcept C104317684 @default.
• W2952628721 hasConcept C126513998 @default.
• W2952628721 hasConcept C138885662 @default.
• W2952628721 hasConcept C141231307 @default.
• W2952628721 hasConcept C142575336 @default.
• W2952628721 hasConcept C150194340 @default.
• W2952628721 hasConcept C162317418 @default.
• W2952628721 hasConcept C179926584 @default.
• W2952628721 hasConcept C194993378 @default.
• W2952628721 hasConcept C2909068217 @default.
• W2952628721 hasConcept C41895202 @default.
• W2952628721 hasConcept C54355233 @default.

• next