Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952659097> ?p ?o ?g. }
- W2952659097 endingPage "e1007872" @default.
- W2952659097 startingPage "e1007872" @default.
- W2952659097 abstract "Innate recognition of invading intracellular pathogens is essential for regulating robust and rapid CD4+ T cell effector function, which is critical for host-mediated immunity. The intracellular apicomplexan parasite, Toxoplasma gondii, is capable of infecting almost any nucleated cell of warm-blooded animals, including humans, and establishing tissue cysts that persist throughout the lifetime of the host. Recognition of T. gondii by TLRs is essential for robust IL-12 and IFN-γ production, two major cytokines involved in host resistance to the parasite. In the murine model of infection, robust IL-12 and IFN-γ production have been largely attributed to T. gondii profilin recognition by the TLR11 and TLR12 heterodimer complex, resulting in Myd88-dependent IL-12 production. However, TLR11 or TLR12 deficiency failed to recapitulate the acute susceptibility to T. gondii infection seen in Myd88-/- mice. T. gondii triggers inflammasome activation in a caspase-1-dependent manner resulting in cytokine release; however, it remains undetermined if parasite-mediated inflammasome activation impacts IFN-γ production and host resistance to the parasite. Using mice which lack different inflammasome components, we observed that the inflammasome played a limited role in host resistance when TLR11 remained functional. Strikingly, in the absence of TLR11, caspase-1 and -11 played a significant role for robust CD4+ TH1-derived IFN-γ responses and host survival. Moreover, we demonstrated that in the absence of TLR11, production of the caspase-1-dependent cytokine IL-18 was sufficient and necessary for CD4+ T cell-derived IFN-γ responses. Mechanistically, we established that T. gondii-mediated activation of the inflammasome and IL-18 were critical to maintain robust CD4+ TH1 IFN-γ responses during parasite infection in the absence of TLR11." @default.
- W2952659097 created "2019-06-27" @default.
- W2952659097 creator A5002914011 @default.
- W2952659097 creator A5041966555 @default.
- W2952659097 creator A5042246091 @default.
- W2952659097 creator A5048851953 @default.
- W2952659097 creator A5088532366 @default.
- W2952659097 date "2019-06-13" @default.
- W2952659097 modified "2023-09-26" @default.
- W2952659097 title "TLR11-independent inflammasome activation is critical for CD4+ T cell-derived IFN-γ production and host resistance to Toxoplasma gondii" @default.
- W2952659097 cites W1571840817 @default.
- W2952659097 cites W1793115003 @default.
- W2952659097 cites W1970123788 @default.
- W2952659097 cites W1970279912 @default.
- W2952659097 cites W1973723338 @default.
- W2952659097 cites W1975032025 @default.
- W2952659097 cites W1983422677 @default.
- W2952659097 cites W1983430686 @default.
- W2952659097 cites W1987535382 @default.
- W2952659097 cites W1988563171 @default.
- W2952659097 cites W1990899125 @default.
- W2952659097 cites W1992113146 @default.
- W2952659097 cites W1992762970 @default.
- W2952659097 cites W1998047654 @default.
- W2952659097 cites W2011541425 @default.
- W2952659097 cites W2013669259 @default.
- W2952659097 cites W2018284639 @default.
- W2952659097 cites W2021361448 @default.
- W2952659097 cites W2028552491 @default.
- W2952659097 cites W2031029755 @default.
- W2952659097 cites W2036018864 @default.
- W2952659097 cites W2038982445 @default.
- W2952659097 cites W2042622445 @default.
- W2952659097 cites W2067873629 @default.
- W2952659097 cites W2074177784 @default.
- W2952659097 cites W2076315468 @default.
- W2952659097 cites W2082288600 @default.
- W2952659097 cites W2089025478 @default.
- W2952659097 cites W2091276411 @default.
- W2952659097 cites W2097673478 @default.
- W2952659097 cites W2099454718 @default.
- W2952659097 cites W2104144288 @default.
- W2952659097 cites W2107277218 @default.
- W2952659097 cites W2111085423 @default.
- W2952659097 cites W2111200149 @default.
- W2952659097 cites W2111260918 @default.
- W2952659097 cites W2126901258 @default.
- W2952659097 cites W2130985618 @default.
- W2952659097 cites W2142713800 @default.
- W2952659097 cites W2149673255 @default.
- W2952659097 cites W2162641910 @default.
- W2952659097 cites W2165098754 @default.
- W2952659097 cites W2170091723 @default.
- W2952659097 cites W2171831396 @default.
- W2952659097 cites W2175794645 @default.
- W2952659097 cites W2192080449 @default.
- W2952659097 cites W2209894880 @default.
- W2952659097 cites W2276849629 @default.
- W2952659097 cites W2462773201 @default.
- W2952659097 cites W2464992606 @default.
- W2952659097 cites W2472801518 @default.
- W2952659097 cites W2730174993 @default.
- W2952659097 cites W2755321238 @default.
- W2952659097 cites W2781922523 @default.
- W2952659097 cites W2783306872 @default.
- W2952659097 cites W2792817623 @default.
- W2952659097 cites W2925100173 @default.
- W2952659097 doi "https://doi.org/10.1371/journal.ppat.1007872" @default.
- W2952659097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6599108" @default.
- W2952659097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31194844" @default.
- W2952659097 hasPublicationYear "2019" @default.
- W2952659097 type Work @default.
- W2952659097 sameAs 2952659097 @default.
- W2952659097 citedByCount "24" @default.
- W2952659097 countsByYear W29526590972020 @default.
- W2952659097 countsByYear W29526590972021 @default.
- W2952659097 countsByYear W29526590972022 @default.
- W2952659097 countsByYear W29526590972023 @default.
- W2952659097 crossrefType "journal-article" @default.
- W2952659097 hasAuthorship W2952659097A5002914011 @default.
- W2952659097 hasAuthorship W2952659097A5041966555 @default.
- W2952659097 hasAuthorship W2952659097A5042246091 @default.
- W2952659097 hasAuthorship W2952659097A5048851953 @default.
- W2952659097 hasAuthorship W2952659097A5088532366 @default.
- W2952659097 hasBestOaLocation W29526590971 @default.
- W2952659097 hasConcept C136449434 @default.
- W2952659097 hasConcept C139964883 @default.
- W2952659097 hasConcept C153726182 @default.
- W2952659097 hasConcept C159654299 @default.
- W2952659097 hasConcept C203014093 @default.
- W2952659097 hasConcept C2776914184 @default.
- W2952659097 hasConcept C2777209026 @default.
- W2952659097 hasConcept C2778128430 @default.
- W2952659097 hasConcept C2778690821 @default.
- W2952659097 hasConcept C2779341262 @default.
- W2952659097 hasConcept C51785407 @default.
- W2952659097 hasConcept C79879829 @default.
- W2952659097 hasConcept C86803240 @default.