FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952684089> ?p ?o ?g. }

• W2952684089 endingPage "4647" @default.
• W2952684089 startingPage "4639" @default.
• W2952684089 abstract "BACKGROUND:Breast cancer is one of the most malignant tumors worldwide. The natural flavonoid diosmetin has been reported to exhibit various pharmacological activities, including anti-cancer effects. This study aimed to investigate the anti-breast cancer effects of diosmetin on MDA-MB-231 cells and to explore the underlying molecular mechanisms of cell apoptosis. MATERIAL AND METHODS:The MDA-MB-231 cells were incubated with diosmetin for 24 h. Then, cell viability and lactate dehydrogenase (LDH) leakage were detected using CCK-8 and LDH assay kits, respectively. Inverted fluorescence microscopy and flow cytometry were used to measure the mitochondrial membrane potential (MMP) and intracellular reactive oxygen species (ROS). Cell apoptosis and cell cycle were determined by flow cytometry. The expressions of apoptosis and cell cycle-related genes were determined by Western blotting and qRT-PCR. RESULTS:The results revealed that diosmetin exerts significant cytotoxic effects on MDA-MB-231 cells, as indicated by decreased cell viability, increased intracellular ROS accumulation and LDH release, as well as cell cycle arrest in G0/G1 phase, inducing mitochondrial dysfunction and apoptosis. Moreover, diosmetin treatment significantly downregulated the expression levels of Bcl-2 and Cyclin D1, and upregulated that of p53, Bax, caspase 3, cleaved caspase 9, and cleaved caspase 3. CONCLUSIONS:These findings demonstrate that diosmetin has anti-proliferative and pro-apoptotic activities against MDA-MB-231 cells via cell cycle arrest and the mitochondria-mediated intrinsic apoptotic pathway. Our results extend the understanding of the anti-tumor mechanism of diosmetin and suggest that it may be of use as an active natural agent for the prevention or treatment of human breast cancer." @default.
• W2952684089 created "2019-06-27" @default.
• W2952684089 creator A5010405556 @default.
• W2952684089 creator A5027145131 @default.
• W2952684089 creator A5035788656 @default.
• W2952684089 creator A5044188620 @default.
• W2952684089 creator A5046254885 @default.
• W2952684089 creator A5073758616 @default.
• W2952684089 creator A5074131698 @default.
• W2952684089 creator A5079201749 @default.
• W2952684089 creator A5082451686 @default.
• W2952684089 date "2019-06-22" @default.
• W2952684089 modified "2023-10-11" @default.
• W2952684089 title "Anti-Proliferation and Pro-Apoptotic Effects of Diosmetin via Modulating Cell Cycle Arrest and Mitochondria-Mediated Intrinsic Apoptotic Pathway in MDA-MB-231 Cells" @default.
• W2952684089 cites W1512072225 @default.
• W2952684089 cites W1543358981 @default.
• W2952684089 cites W1567758417 @default.
• W2952684089 cites W1630176173 @default.
• W2952684089 cites W1903875142 @default.
• W2952684089 cites W1965134354 @default.
• W2952684089 cites W1996499700 @default.
• W2952684089 cites W2002746961 @default.
• W2952684089 cites W2058315403 @default.
• W2952684089 cites W2086144679 @default.
• W2952684089 cites W2086705790 @default.
• W2952684089 cites W2098212299 @default.
• W2952684089 cites W2119877295 @default.
• W2952684089 cites W2146181702 @default.
• W2952684089 cites W2255030634 @default.
• W2952684089 cites W2264877802 @default.
• W2952684089 cites W2299652449 @default.
• W2952684089 cites W2301585149 @default.
• W2952684089 cites W2527169367 @default.
• W2952684089 cites W2549607734 @default.
• W2952684089 cites W2565328088 @default.
• W2952684089 cites W2592119850 @default.
• W2952684089 cites W2605807388 @default.
• W2952684089 cites W2771318378 @default.
• W2952684089 cites W2789697804 @default.
• W2952684089 cites W2792886364 @default.
• W2952684089 cites W2795665651 @default.
• W2952684089 cites W2808699914 @default.
• W2952684089 cites W2883183744 @default.
• W2952684089 doi "https://doi.org/10.12659/msm.914058" @default.
• W2952684089 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6601365" @default.
• W2952684089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31228347" @default.
• W2952684089 hasPublicationYear "2019" @default.
• W2952684089 type Work @default.
• W2952684089 sameAs 2952684089 @default.
• W2952684089 citedByCount "16" @default.
• W2952684089 countsByYear W29526840892019 @default.
• W2952684089 countsByYear W29526840892020 @default.
• W2952684089 countsByYear W29526840892021 @default.
• W2952684089 countsByYear W29526840892022 @default.
• W2952684089 countsByYear W29526840892023 @default.
• W2952684089 crossrefType "journal-article" @default.
• W2952684089 hasAuthorship W2952684089A5010405556 @default.
• W2952684089 hasAuthorship W2952684089A5027145131 @default.
• W2952684089 hasAuthorship W2952684089A5035788656 @default.
• W2952684089 hasAuthorship W2952684089A5044188620 @default.
• W2952684089 hasAuthorship W2952684089A5046254885 @default.
• W2952684089 hasAuthorship W2952684089A5073758616 @default.
• W2952684089 hasAuthorship W2952684089A5074131698 @default.
• W2952684089 hasAuthorship W2952684089A5079201749 @default.
• W2952684089 hasAuthorship W2952684089A5082451686 @default.
• W2952684089 hasBestOaLocation W29526840892 @default.
• W2952684089 hasConcept C105696609 @default.
• W2952684089 hasConcept C1491633281 @default.
• W2952684089 hasConcept C153911025 @default.
• W2952684089 hasConcept C190283241 @default.
• W2952684089 hasConcept C29537977 @default.
• W2952684089 hasConcept C53227056 @default.
• W2952684089 hasConcept C553184892 @default.
• W2952684089 hasConcept C55493867 @default.
• W2952684089 hasConcept C62112901 @default.
• W2952684089 hasConcept C79879829 @default.
• W2952684089 hasConcept C86803240 @default.
• W2952684089 hasConcept C95444343 @default.
• W2952684089 hasConceptScore W2952684089C105696609 @default.
• W2952684089 hasConceptScore W2952684089C1491633281 @default.
• W2952684089 hasConceptScore W2952684089C153911025 @default.
• W2952684089 hasConceptScore W2952684089C190283241 @default.
• W2952684089 hasConceptScore W2952684089C29537977 @default.
• W2952684089 hasConceptScore W2952684089C53227056 @default.
• W2952684089 hasConceptScore W2952684089C553184892 @default.
• W2952684089 hasConceptScore W2952684089C55493867 @default.
• W2952684089 hasConceptScore W2952684089C62112901 @default.
• W2952684089 hasConceptScore W2952684089C79879829 @default.
• W2952684089 hasConceptScore W2952684089C86803240 @default.
• W2952684089 hasConceptScore W2952684089C95444343 @default.
• W2952684089 hasLocation W29526840891 @default.
• W2952684089 hasLocation W29526840892 @default.
• W2952684089 hasLocation W29526840893 @default.
• W2952684089 hasLocation W29526840894 @default.
• W2952684089 hasOpenAccess W2952684089 @default.
• W2952684089 hasPrimaryLocation W29526840891 @default.
• W2952684089 hasRelatedWork W2350294409 @default.
• W2952684089 hasRelatedWork W2351774314 @default.

• next