Matches in SemOpenAlex for { <https://semopenalex.org/work/W2952690783> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W2952690783 abstract "The binding of basic fibroblast growth factor (FGF-2) to its cell surface receptor (CSR) and subsequent signal transduction is known to be enhanced by Heparan Sulfate Proteoglycans (HSPGs). HSPGs bind FGF-2 with low affinity and likely impact CSR-mediated signaling via stabilization of FGF-2-CSR complexes via association with both the ligand and the receptor. What is unknown is whether HSPG associates with CSR in the absence of FGF-2. In this paper, we determine conditions by which pre-association would impact CSR-FGF-2-HSPG triad formation assuming diffusion-limited surface reactions. Using mean-field rate equations, we show that (i) when [HSPG] is much higher than [CSR], the presence of pre-formed complexes does not affect the steady state of FGF-2 binding, and (ii) when the concentrations are comparable, the presence of pre-formed complexes substantially increases the steady state concentration of FGF-2 bound to CSR. These findings are supported by explicit cellular automaton simulations, which justify the mean-field treatment. We discuss the advantages of such a two-receptor system compared to a single receptor model, when the parameters are comparable. Further, we speculate that the observed high concentration of HSPG in intact cells ([HSPG] ~ 100[CSR]) provides a way to ensure that the binding levels of FGF-2 to its signaling receptor remains high, irrespective of the presence of pre-formed CSR-HSPG complexes on the cell surface, while allowing the cell to finely tune the response to FGF-2 via down-regulation of the signaling receptor." @default.
- W2952690783 created "2019-06-27" @default.
- W2952690783 creator A5002324032 @default.
- W2952690783 creator A5007408692 @default.
- W2952690783 creator A5042236151 @default.
- W2952690783 date "2003-08-18" @default.
- W2952690783 modified "2023-10-10" @default.
- W2952690783 title "Ligand-induced Coupling versus Receptor Pre-association: Cellular automaton simulations of FGF-2 binding" @default.
- W2952690783 hasPublicationYear "2003" @default.
- W2952690783 type Work @default.
- W2952690783 sameAs 2952690783 @default.
- W2952690783 citedByCount "0" @default.
- W2952690783 crossrefType "posted-content" @default.
- W2952690783 hasAuthorship W2952690783A5002324032 @default.
- W2952690783 hasAuthorship W2952690783A5007408692 @default.
- W2952690783 hasAuthorship W2952690783A5042236151 @default.
- W2952690783 hasConcept C116569031 @default.
- W2952690783 hasConcept C12554922 @default.
- W2952690783 hasConcept C147789679 @default.
- W2952690783 hasConcept C1491633281 @default.
- W2952690783 hasConcept C170493617 @default.
- W2952690783 hasConcept C185592680 @default.
- W2952690783 hasConcept C55493867 @default.
- W2952690783 hasConcept C62478195 @default.
- W2952690783 hasConcept C74373430 @default.
- W2952690783 hasConcept C8171440 @default.
- W2952690783 hasConcept C86803240 @default.
- W2952690783 hasConcept C95444343 @default.
- W2952690783 hasConceptScore W2952690783C116569031 @default.
- W2952690783 hasConceptScore W2952690783C12554922 @default.
- W2952690783 hasConceptScore W2952690783C147789679 @default.
- W2952690783 hasConceptScore W2952690783C1491633281 @default.
- W2952690783 hasConceptScore W2952690783C170493617 @default.
- W2952690783 hasConceptScore W2952690783C185592680 @default.
- W2952690783 hasConceptScore W2952690783C55493867 @default.
- W2952690783 hasConceptScore W2952690783C62478195 @default.
- W2952690783 hasConceptScore W2952690783C74373430 @default.
- W2952690783 hasConceptScore W2952690783C8171440 @default.
- W2952690783 hasConceptScore W2952690783C86803240 @default.
- W2952690783 hasConceptScore W2952690783C95444343 @default.
- W2952690783 hasLocation W29526907831 @default.
- W2952690783 hasOpenAccess W2952690783 @default.
- W2952690783 hasPrimaryLocation W29526907831 @default.
- W2952690783 hasRelatedWork W1968226123 @default.
- W2952690783 hasRelatedWork W1977789593 @default.
- W2952690783 hasRelatedWork W1981358208 @default.
- W2952690783 hasRelatedWork W1995615350 @default.
- W2952690783 hasRelatedWork W2015335081 @default.
- W2952690783 hasRelatedWork W2016193986 @default.
- W2952690783 hasRelatedWork W2018654805 @default.
- W2952690783 hasRelatedWork W2020453105 @default.
- W2952690783 hasRelatedWork W2025514950 @default.
- W2952690783 hasRelatedWork W2026557156 @default.
- W2952690783 hasRelatedWork W2032719221 @default.
- W2952690783 hasRelatedWork W2050911729 @default.
- W2952690783 hasRelatedWork W2054550915 @default.
- W2952690783 hasRelatedWork W2061786230 @default.
- W2952690783 hasRelatedWork W2064631702 @default.
- W2952690783 hasRelatedWork W2135296230 @default.
- W2952690783 hasRelatedWork W2137887953 @default.
- W2952690783 hasRelatedWork W2151044008 @default.
- W2952690783 hasRelatedWork W2162666957 @default.
- W2952690783 hasRelatedWork W3207744618 @default.
- W2952690783 isParatext "false" @default.
- W2952690783 isRetracted "false" @default.
- W2952690783 magId "2952690783" @default.
- W2952690783 workType "article" @default.