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- W2952694 abstract "Bacterial pneumonia is a common complication of influenza A infection. We create an ODE model of bacterial infection with state variables representing the respective levels of bacteria, impaired and active neutrophils, and the anti-inflammatory molecule interleukin 10 (IL-10). After fitting the parameters, we obtain a model that demonstrates bistability between states of health and chronic bacterial infection. The fitted model also closely reproduces IL-10 data obtained from a model of mice inoculated with a strain of influenza A virus. Additionally, we develop a different model similar to the first but with stochastic intake of bacteria to represent the inhalation of small amounts of bacteria into the lungs many times daily. We find a set of parameters for which the second model produces a fit to the IAV IL-10 data." @default.
- W2952694 created "2016-06-24" @default.
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- W2952694 date "2011-06-06" @default.
- W2952694 modified "2023-09-26" @default.
- W2952694 title "A Model of Bacterial Superinfection in an Influenza-Infected Host" @default.
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